Jessica Weafer1, Mark T Fillmore. 1. Department of Psychology, University of Kentucky, Lexington, KY, 40506-0044, USA.
Abstract
RATIONALE: Research has begun to examine how acute cognitive impairment from alcohol could contribute to alcohol abuse. Specifically, alcohol-induced impairment of inhibitory control could compromise the drinker's ability to stop the self-administration of alcohol, increasing the risk of binge drinking. OBJECTIVE: The present study was designed to test this hypothesis by examining the relation between acute alcohol impairment of inhibitory control and alcohol consumption during a single drinking episode. MATERIALS AND METHODS:Twenty-six healthy adults performed a cued go/no-go task that measured inhibitory control. The study tested the degree to which their inhibitory control was impaired by a moderate dose of alcohol (0.65 g/kg) versus a placebo and the extent to which individual differences in this impairment predicted levels of alcohol consumption as assessed by ad lib drinking in the laboratory. RESULTS: In accord with the hypothesis, greater impairment of inhibitory control from alcohol was associated with increased ad lib consumption. CONCLUSION: Acute impairment of inhibitory control might be an important cognitive effect that contributes to abuse in addition to the positive rewarding effects of the drug.
RCT Entities:
RATIONALE: Research has begun to examine how acute cognitive impairment from alcohol could contribute to alcohol abuse. Specifically, alcohol-induced impairment of inhibitory control could compromise the drinker's ability to stop the self-administration of alcohol, increasing the risk of binge drinking. OBJECTIVE: The present study was designed to test this hypothesis by examining the relation between acute alcohol impairment of inhibitory control and alcohol consumption during a single drinking episode. MATERIALS AND METHODS: Twenty-six healthy adults performed a cued go/no-go task that measured inhibitory control. The study tested the degree to which their inhibitory control was impaired by a moderate dose of alcohol (0.65 g/kg) versus a placebo and the extent to which individual differences in this impairment predicted levels of alcohol consumption as assessed by ad lib drinking in the laboratory. RESULTS: In accord with the hypothesis, greater impairment of inhibitory control from alcohol was associated with increased ad lib consumption. CONCLUSION: Acute impairment of inhibitory control might be an important cognitive effect that contributes to abuse in addition to the positive rewarding effects of the drug.
Authors: G F Koob; M Rocio; A Carrera; L H Gold; C J Heyser; C Maldonado-Irizarry; A Markou; L H Parsons; A J Roberts; G Schulteis; L Stinus; J R Walker; R Weissenborn; F Weiss Journal: J Psychopharmacol Date: 1998 Impact factor: 4.153
Authors: Marc A Schuckit; Susan Tapert; Scott C Matthews; Martin P Paulus; Neil J Tolentino; Tom L Smith; Ryan S Trim; Shana Hall; Alan Simmons Journal: Alcohol Clin Exp Res Date: 2011-10-17 Impact factor: 3.455
Authors: Gabriela Gan; Alvaro Guevara; Michael Marxen; Maike Neumann; Elisabeth Jünger; Andrea Kobiella; Eva Mennigen; Maximilian Pilhatsch; Daniel Schwarz; Ulrich S Zimmermann; Michael N Smolka Journal: Biol Psychiatry Date: 2014-01-15 Impact factor: 13.382
Authors: Benjamin L Berey; Robert F Leeman; Brian Pittman; Nicholas Franco; Suchitra Krishnan-Sarin Journal: Alcohol Alcohol Date: 2019-03-01 Impact factor: 2.826
Authors: Rachel L Gunn; Alyssa L Norris; Alexander Sokolovsky; Lauren Micalizzi; Jennifer E Merrill; Nancy P Barnett Journal: Psychol Addict Behav Date: 2018-10-25