| Literature DB >> 18758134 |
Nobuaki Egashira1, Ryoko Okuno, Moe Abe, Michihiko Matsushita, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Ryoji Nishimura, Yoshiaki Matsumoto, Michihiro Fujiwara.
Abstract
In the present study, we examined the effects of calcium-channel antagonists on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Amlodipine (10 mg/kg, i.p.), cilnidipine (10 mg/kg, i.p.), nilvadipine (3 and 10 mg/kg, i.p.), and flunarizine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior in mice. These results suggest that calcium channels may be involved in the marble-burying behavior.Entities:
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Year: 2008 PMID： 18758134 DOI： 10.1254/jphs.08160sc
Source DB: PubMed Journal: J Pharmacol Sci ISSN： 1347-8613 Impact factor: 3.337