Literature DB >> 18757096

Aberrant DNA methylation of the transcription factor C/EBPalpha in acute myelogenous leukemia.

Edgar Jost1, Nicole do O, Stefan Wilop, James G Herman, Rainhardt Osieka, Oliver Galm.   

Abstract

We investigated the methylation status of the CCAAT/enhancer binding protein alpha (C/EBPalpha) promoter region near the transcription start site in acute myelogenous leukemia (AML). In hematopoietic tumor cell lines, CpG island hypermethylation of the proximal C/EBPalpha promoter region was associated with transcriptional silencing, and treatment with the demethylating agent 5-aza-2'-deoxycytidine resulted in C/EBPalpha reexpression and promoter demethylation. Aberrant methylation of the C/EBPalpha promoter region occurred in 10/80 diagnostic AML samples, and there was an inverse correlation between aberrant methylation of C/EBPalpha and the negative cell cycle regulator p15. Our results provide further evidence for epigenetic dysregulation of C/EBPalpha in AML.

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Year:  2008        PMID： 18757096     DOI： 10.1016/j.leukres.2008.07.027

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  11 in total

1.  The CEBPA gene is down-regulated in acute promyelocytic leukemia and its upstream promoter, but not the core promoter, is highly methylated.

Authors:  Bárbara Amélia Santana-Lemos; Ana Paula Alencar de Lima Lange; Mariana Tereza de Lira Benício; Thiago Donizete da Silva José; Antônio Roberto Lucena-Araújo; Alexandre Krause; Carolina Hassibe Thomé; Eduardo Magalhães Rego
Journal:  Haematologica       Date:  2010-12-06       Impact factor: 9.941

2.  Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells.

Authors:  Kyoungsub Song; Chang Han; Jinqiang Zhang; Dongdong Lu; Srikanta Dash; Mark Feitelson; Kyu Lim; Tong Wu
Journal:  Hepatology       Date:  2013-09-17       Impact factor: 17.425

3.  PU.1 activation relieves GATA-1-mediated repression of Cebpa and Cbfb during leukemia differentiation.

Authors:  Pavel Burda; Nikola Curik; Juraj Kokavec; Petra Basova; Dana Mikulenkova; Arthur I Skoultchi; Jiri Zavadil; Tomas Stopka
Journal:  Mol Cancer Res       Date:  2009-10-13       Impact factor: 5.852

4.  The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.

Authors:  Magali Humbert; Elena A Federzoni; Adrian Britschgi; Anna M Schläfli; Peter J M Valk; Thomas Kaufmann; Torsten Haferlach; Gerhard Behre; Hans-Uwe Simon; Bruce E Torbett; Martin F Fey; Mario P Tschan
Journal:  J Leukoc Biol       Date:  2013-09-13       Impact factor: 4.962

Review 5.  The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis.

Authors:  Danjie Jiang; Qingxiao Hong; Yusheng Shen; Yan Xu; Huangkai Zhu; Yirun Li; Chunjing Xu; Guifang Ouyang; Shiwei Duan
Journal:  PLoS One       Date:  2014-05-08       Impact factor: 3.240

6.  CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma.

Authors:  Guo-Dong Lu; Yang Huey Ang; Jing Zhou; Jegadeesan Tamilarasi; Benedict Yan; Yaw Chyn Lim; Supriya Srivastava; Manuel Salto-Tellez; Kam M Hui; Han-Ming Shen; Long N Nguyen; Bryan C Tan; David L Silver; Shing Chuan Hooi
Journal:  Hepatology       Date:  2015-01-30       Impact factor: 17.425

7.  Integrative Analysis of Multi-Omics Identified the Prognostic Biomarkers in Acute Myelogenous Leukemia.

Authors:  Jiafeng Zheng; Tongqiang Zhang; Wei Guo; Caili Zhou; Xiaojian Cui; Long Gao; Chunquan Cai; Yongsheng Xu
Journal:  Front Oncol       Date:  2020-12-10       Impact factor: 6.244

8.  Integrative Analysis of DNA Methylation and Gene Expression Profiling Data Reveals Candidate Methylation-Regulated Genes in Hepatoblastoma.

Authors:  Jian-Yao Wang; Jing Lao; Yu Luo; Jing-Jie Guo; Hao Cheng; Hong-Yan Zhang; Jun Yao; Xiao-Peng Ma; Bin Wang
Journal:  Int J Gen Med       Date:  2021-12-06

9.  Methylation status of DDIT3 gene in chronic myeloid leukemia.

Authors:  Ya-li Wang; Jun Qian; Jiang Lin; Dong-ming Yao; Zhen Qian; Zhao-hui Zhu; Jian-yong Li
Journal:  J Exp Clin Cancer Res       Date:  2010-05-23

10.  Frequency and prognostic impact of CEBPA proximal, distal and core promoter methylation in normal karyotype AML: a study on 623 cases.

Authors:  Annette Fasan; Tamara Alpermann; Claudia Haferlach; Vera Grossmann; Andreas Roller; Alexander Kohlmann; Christiane Eder; Wolfgang Kern; Torsten Haferlach; Susanne Schnittger
Journal:  PLoS One       Date:  2013-02-01       Impact factor: 3.240
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