INTRODUCTION: The present study was undertaken to evaluate the status of lipid peroxidation and antioxidants as biomarkers in human plasma. METHODS: The extent of lipid peroxidation as evidenced by the formation of thiobarbituric acid reactive substances (TBARS) and conjugated dienes (CD) as well as the status of the antioxidants superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx) and glutathione S-transferase (GST) in serum samples of 40 breast cancer patients in and around Coimbatore, India, were studied. Controls consisted of members of the public with no previous history of breast cancer or other cancer-related diseases. RESULTS: The plasma samples of the breast cancer patients showed enhanced level of lipid peroxidation when compared to the corresponding controls. This was accompanied by a significant elevation in both enzymic and non-enzymic antioxidants. CONCLUSION: These findings indicate the significant increase in lipid peroxidation as evidenced by the level of TBARS and antioxidant status such as elevated SOD, CAT, GPx, GSH and GST in samples from breast cancer patients compared to controls.
INTRODUCTION: The present study was undertaken to evaluate the status of lipid peroxidation and antioxidants as biomarkers in human plasma. METHODS: The extent of lipid peroxidation as evidenced by the formation of thiobarbituric acid reactive substances (TBARS) and conjugated dienes (CD) as well as the status of the antioxidants superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx) and glutathione S-transferase (GST) in serum samples of 40 breast cancerpatients in and around Coimbatore, India, were studied. Controls consisted of members of the public with no previous history of breast cancer or other cancer-related diseases. RESULTS: The plasma samples of the breast cancerpatients showed enhanced level of lipid peroxidation when compared to the corresponding controls. This was accompanied by a significant elevation in both enzymic and non-enzymic antioxidants. CONCLUSION: These findings indicate the significant increase in lipid peroxidation as evidenced by the level of TBARS and antioxidant status such as elevated SOD, CAT, GPx, GSH and GST in samples from breast cancerpatients compared to controls.
Authors: Barbara Tomasello; Giuseppe Antonio Malfa; Angela Strazzanti; Santi Gangi; Claudia Di Giacomo; Francesco Basile; Marcella Renis Journal: Oncol Lett Date: 2016-11-30 Impact factor: 2.967
Authors: Mora Murri; Eduardo García-Fuentes; José Manuel García-Almeida; Lourdes Garrido-Sánchez; María Dolores Mayas; Rosa Bernal; Francisco J Tinahones Journal: Obes Surg Date: 2010-03 Impact factor: 4.129
Authors: Marco Peluso; Armelle Munnia; Gabriella G Risso; Sandra Catarzi; Sara Piro; Marcello Ceppi; Roger W Giese; Beniamino Brancato Journal: Free Radic Res Date: 2011-01-21
Authors: Anatoly Samoylenko; Jubayer Al Hossain; Daniela Mennerich; Sakari Kellokumpu; Jukka Kalervo Hiltunen; Thomas Kietzmann Journal: Antioxid Redox Signal Date: 2013-04-15 Impact factor: 8.401