BACKGROUND: Inflammatory processes play a fundamental role in the development of cardiovascular disease. OBJECTIVES: To compare the associations of complement C3 and C-reactive protein (CRP) with myocardial infarction (MI) and cardiovascular risk factors. METHODS: 342 Caucasian male subjects aged < or =65 years with MI and 193 Caucasian age matched healthy male control subjects were recruited. C3 and CRP were measured by ELISA. RESULTS: C3 and CRP were significantly higher (p<0.001) in patients compared with healthy subjects (patients vs. healthy subjects, C3: 1.22gL(-1) vs. 1.00gL(-1); CRP: 1.41mgL(-1) vs. 0.72mgL(-1)). In a logistic regression model, including conventional cardiovascular risk factors, C3 was independently associated with MI (odds ratio for a 1 S.D. increase in C3: 2.29 [1.58, 2.92]); and this association remained after including CRP and/or fibrinogen in the model. CRP was independently associated with MI after accounting for conventional risk factors (odds ratio for a 1 S.D. increase in CRP: 1.47 [1.16, 1.87]), however, this association was lost when C3and/or fibrinogen were included in the model. Receiver operating characteristic (ROC) analysis indicated that the model which best predicted MI was the model including C3 and fibrinogen. CONCLUSIONS: These data suggest that elevated C3 is independently associated with MI and that elevated C3 may be a more specific marker of the inflammatory processes underpinning MI than CRP.
BACKGROUND: Inflammatory processes play a fundamental role in the development of cardiovascular disease. OBJECTIVES: To compare the associations of complement C3 and C-reactive protein (CRP) with myocardial infarction (MI) and cardiovascular risk factors. METHODS: 342 Caucasian male subjects aged < or =65 years with MI and 193 Caucasian age matched healthy male control subjects were recruited. C3 and CRP were measured by ELISA. RESULTS: C3 and CRP were significantly higher (p<0.001) in patients compared with healthy subjects (patients vs. healthy subjects, C3: 1.22gL(-1) vs. 1.00gL(-1); CRP: 1.41mgL(-1) vs. 0.72mgL(-1)). In a logistic regression model, including conventional cardiovascular risk factors, C3 was independently associated with MI (odds ratio for a 1 S.D. increase in C3: 2.29 [1.58, 2.92]); and this association remained after including CRP and/or fibrinogen in the model. CRP was independently associated with MI after accounting for conventional risk factors (odds ratio for a 1 S.D. increase in CRP: 1.47 [1.16, 1.87]), however, this association was lost when C3and/or fibrinogen were included in the model. Receiver operating characteristic (ROC) analysis indicated that the model which best predicted MI was the model including C3 and fibrinogen. CONCLUSIONS: These data suggest that elevated C3 is independently associated with MI and that elevated C3 may be a more specific marker of the inflammatory processes underpinning MI than CRP.
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