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Literature DB >> 18754697

Current management of tuberous sclerosis complex.

Abstract

Tuberous sclerosis complex (TSC) is an important cause of epilepsy, autism, and renal and pulmonary disease in children and adults. The clinical course of TSC and the prognosis and appropriate therapy for TSC patients are often different than that for individuals with epilepsy, renal tumors, or interstitial lung disease from other causes. This article reviews the current therapeutic recommendations for medical and surgical management of neurologic, renal, and pulmonary manifestations of TSC. In addition, recent clinical trials using inhibitors of the mammalian target of rapamycin (mTOR) have demonstrated regression of astrocytomas, angiofibromas, and angiomyoliomas, as well as improved pulmonary function in persons with TSC.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18754697 DOI： 10.2165/00148581-200810050-00004

Source DB: PubMed Journal: Paediatr Drugs ISSN： 1174-5878 Impact factor: 3.022

117 in total

1. Doxycycline treatment for lymphangioleiomyomatosis with urinary monitoring for MMPs.

Authors: Marsha A Moses; Jay Harper; Judah Folkman
Journal: N Engl J Med Date: 2006-06-15 Impact factor: 91.245

2. Tuberous sclerosis.

Authors: John R W Yates
Journal: Eur J Hum Genet Date: 2006-07-26 Impact factor: 4.246

3. Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex.

Authors: Eleanor Hancock; Finbar O'Callaghan; John P Osborne
Journal: J Child Neurol Date: 2005-01 Impact factor: 1.987

4. Mutational and radiographic analysis of pulmonary disease consistent with lymphangioleiomyomatosis and micronodular pneumocyte hyperplasia in women with tuberous sclerosis.

Authors: D N Franz; A Brody; C Meyer; J Leonard; G Chuck; S Dabora; G Sethuraman; T V Colby; D J Kwiatkowski; F X McCormack
Journal: Am J Respir Crit Care Med Date: 2001-08-15 Impact factor: 21.405

5. Neuro-epileptic determinants of autism spectrum disorders in tuberous sclerosis complex.

Authors: Patrick F Bolton; Rebecca J Park; J Nicholas P Higgins; Paul D Griffiths; Andrew Pickles
Journal: Brain Date: 2002-06 Impact factor: 13.501

6. Impaired synaptic plasticity in a rat model of tuberous sclerosis.

Authors: Christian von der Brelie; Robert Waltereit; Lian Zhang; Heinz Beck; Timo Kirschstein
Journal: Eur J Neurosci Date: 2006-02 Impact factor: 3.386

7. Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function.

Authors: Lynsey Meikle; Kristen Pollizzi; Anna Egnor; Ioannis Kramvis; Heidi Lane; Mustafa Sahin; David J Kwiatkowski
Journal: J Neurosci Date: 2008-05-21 Impact factor: 6.167

8. Identification and characterization of the tuberous sclerosis gene on chromosome 16.

Authors:
Journal: Cell Date: 1993-12-31 Impact factor: 41.582

9. Levetiracetam as adjunctive antiepileptic therapy for patients with tuberous sclerosis complex: a retrospective open-label trial.

Authors: James J Collins; Cynthia Tudor; Jennifer M Leonard; Gail Chuck; David Neal Franz
Journal: J Child Neurol Date: 2006-01 Impact factor: 1.987

10. Rapid regrowth of solitary subependymal giant cell astrocytoma--case report.

Authors: Keizo Yamamoto; Kazumichi Yamada; Tadashi Nakahara; Akira Ishihara; Shuichi Takaki; Masato Kochi; Yukitaka Ushio
Journal: Neurol Med Chir (Tokyo) Date: 2002-05 Impact factor: 1.742

15 in total

Review 1. Neurosurgical treatment of tuberous sclerosis complex lesions.

Authors: Ignacio Pascual-Castroviejo
Journal: Childs Nerv Syst Date: 2011-05-24 Impact factor: 1.475

Review 2. Everolimus: in patients with subependymal giant cell astrocytoma associated with tuberous sclerosis complex.

Authors: Monique P Curran
Journal: Paediatr Drugs Date: 2012-02-01 Impact factor: 3.022

Review 3. Everolimus tablets for patients with subependymal giant cell astrocytoma.

Authors: Scott G Turner; Katherine B Peters; James J Vredenburgh; Annick Desjardins; Henry S Friedman; David A Reardon
Journal: Expert Opin Pharmacother Date: 2011-08-01 Impact factor: 3.889

4. Management of CNS-related Disease Manifestations in Patients With Tuberous Sclerosis Complex.

Authors: Darcy A Krueger
Journal: Curr Treat Options Neurol Date: 2013-10 Impact factor: 3.598

Review 5. Molecular therapies for tuberous sclerosis and neurofibromatosis.

Authors: David Neal Franz; Brian D Weiss
Journal: Curr Neurol Neurosci Rep Date: 2012-06 Impact factor: 5.081

6. Recommendations for the radiological diagnosis and follow-up of neuropathological abnormalities associated with tuberous sclerosis complex.

Authors: Àlex Rovira; María Luz Ruiz-Falcó; Elena García-Esparza; Eduardo López-Laso; Alfons Macaya; Ignacio Málaga; Élida Vázquez; Josefina Vicente
Journal: J Neurooncol Date: 2014-04-27 Impact factor: 4.130