OBJECTIVE: To determine maternal serum placental protein 13 (PP13) in normal pregnancy and preeclampsia. METHODS: A prospective, longitudinal study with 41 normal pregnant women, 18 cases with preterm delivery or cervix insufficiency and 4 with developing late-onset preeclampsia. Six hundred and sixty-six maternal blood samples were obtained every 2-4 weeks starting at 5-8 weeks gestation (10-12 samples/patient) and tested for serum PP13 by ELISA. RESULTS: In normal pregnant women delivering at term, median maternal serum PP13 levels were growing from 166 to 202 pg/ml and 382 pg/ml in the first, second and third trimester, respectively. Preeclamptic women had significantly reduced PP13 levels in the first trimester (multiples of median of 0.14 at 7-8 weeks; p = 0.005 compared to normal). PP13 in the third trimester was significantly higher compared to normal at 35-36 weeks with PP13 multiples of median of 1.79. CONCLUSION: This preliminary study indicates that low levels of PP13 in early pregnancy identify at-risk pregnancies, whereas high levels precede the syndrome in late pregnancy and suggest syncytiotrophoblast necrosis. Copyright 2008 S. Karger AG, Basel.
OBJECTIVE: To determine maternal serum placental protein 13 (PP13) in normal pregnancy and preeclampsia. METHODS: A prospective, longitudinal study with 41 normal pregnant women, 18 cases with preterm delivery or cervix insufficiency and 4 with developing late-onset preeclampsia. Six hundred and sixty-six maternal blood samples were obtained every 2-4 weeks starting at 5-8 weeks gestation (10-12 samples/patient) and tested for serum PP13 by ELISA. RESULTS: In normal pregnant women delivering at term, median maternal serum PP13 levels were growing from 166 to 202 pg/ml and 382 pg/ml in the first, second and third trimester, respectively. Preeclamptic women had significantly reduced PP13 levels in the first trimester (multiples of median of 0.14 at 7-8 weeks; p = 0.005 compared to normal). PP13 in the third trimester was significantly higher compared to normal at 35-36 weeks with PP13 multiples of median of 1.79. CONCLUSION: This preliminary study indicates that low levels of PP13 in early pregnancy identify at-risk pregnancies, whereas high levels precede the syndrome in late pregnancy and suggest syncytiotrophoblast necrosis. Copyright 2008 S. Karger AG, Basel.
Authors: Leslie Myatt; Rebecca G Clifton; James M Roberts; Catherine Y Spong; John C Hauth; Michael W Varner; John M Thorp; Brian M Mercer; Alan M Peaceman; Susan M Ramin; Marshall W Carpenter; Jay D Iams; Anthony Sciscione; Margaret Harper; Jorge E Tolosa; George Saade; Yoram Sorokin; Garland D Anderson Journal: Obstet Gynecol Date: 2012-06 Impact factor: 7.661
Authors: Mirian Mendoza; Dongli Lu; Angela Ballesteros; Sandra M Blois; Kelsey Abernathy; Chiguang Feng; Charles J Dimitroff; Jonathan Zmuda; Maria Panico; Anne Dell; Gerardo R Vasta; Stuart M Haslam; Gabriela Dveksler Journal: Glycobiology Date: 2020-10-21 Impact factor: 4.313