Literature DB >> 1875339

Synthesis and DNA-binding properties of polyamine analogues.

M L Edwards1, R D Snyder, D M Stemerick.   

Abstract

The synthesis of a series of novel polyamine analogues is reported. The DNA binding of these compounds and a variety of other polyamines were compared with their IC50 values against HeLa cell. There seemed to be no apparent correlation between the DNA binding and toxicity against HeLa cells.

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Year:  1991        PMID: 1875339     DOI: 10.1021/jm00112a016

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  5 in total

Review 1.  Recent advances in the development of polyamine analogues as antitumor agents.

Authors:  Robert A Casero; Patrick M Woster
Journal:  J Med Chem       Date:  2009-08-13       Impact factor: 7.446

2.  Cationic facial amphiphiles: a promising class of transfection agents.

Authors:  S Walker; M J Sofia; R Kakarla; N A Kogan; L Wierichs; C B Longley; K Bruker; H R Axelrod; S Midha; S Babu; D Kahne
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-20       Impact factor: 11.205

Review 3.  Design of polyamine-based therapeutic agents: new targets and new directions.

Authors:  M D Thulani Senanayake; Hemali Amunugama; Tracey D Boncher; Robert A Casero; Patrick M Woster
Journal:  Essays Biochem       Date:  2009-11-04       Impact factor: 8.000

4.  Investigations of the mechanism by which mammalian cell growth is inhibited by N1N12-bis(ethyl)spermine.

Authors:  L Albanese; R J Bergeron; A E Pegg
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

5.  Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells.

Authors:  Woonyoung Choi; Eugene W Gerner; Latha Ramdas; Jheri Dupart; Jennifer Carew; Lynsey Proctor; Peng Huang; Wei Zhang; Stanley R Hamilton
Journal:  J Biol Chem       Date:  2004-11-16       Impact factor: 5.157

  5 in total

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