Literature DB >> 18752959

In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.

Carlos M Meléndez Gómez1, Vladimir V Kouznetsov, Maximiliano A Sortino, Sandra L Alvarez, Susana A Zacchino.   

Abstract

Diverse polyfunctionalized quinolines, easily prepared using Lewis acid-catalyzed imino Diels-Alder reactions between corresponding aldimines, were tested for antifungal properties against standardized as well as clinical isolates of clinically important fungi. Among them, 4-pyridyl derivatives displayed the best activities mainly against dermatophytes. The activity appears not to be related neither to the lipophilicity nor to the basicity of compounds.

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Year:  2008        PMID： 18752959     DOI： 10.1016/j.bmc.2008.07.079

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

1.  6,8-Dibromo-quinoline.

Authors:  Ismail Celik; Mehmet Akkurt; Osman Cakmak; Salih Okten; Santiago García-Granda
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-31

2.  First synthesis of 2-(benzofuran-2-yl)-6,7-methylene dioxyquinoline-3-carboxylic acid derivatives.

Authors:  Wentao Gao; Jia Liu; Yun Jiang; Yang Li
Journal:  Beilstein J Org Chem       Date:  2011-02-15       Impact factor: 2.883

3.  Inhibitors of the Detoxifying Enzyme of the Phytoalexin Brassinin Based on Quinoline and Isoquinoline Scaffolds.

Authors:  M Soledade C Pedras; Abbas Abdoli; Vijay K Sarma-Mamillapalle
Journal:  Molecules       Date:  2017-08-14       Impact factor: 4.411

Review 4.  Advancements in the synthesis of fused tetracyclic quinoline derivatives.

Authors:  Ramadan A Mekheimer; Mariam A Al-Sheikh; Hanadi Y Medrasi; Kamal U Sadek
Journal:  RSC Adv       Date:  2020-05-27       Impact factor: 4.036

5.  Investigation of Antifungal Properties of Synthetic Dimethyl-4-Bromo-1-(Substituted Benzoyl) Pyrrolo[1,2-a] Quinoline-2,3-Dicarboxylates Analogues: Molecular Docking Studies and Conceptual DFT-Based Chemical Reactivity Descriptors and Pharmacokinetics Evaluation.

Authors:  Vijayakumar Uppar; Sandeep Chandrashekharappa; Chandan Shivamallu; Sushma P; Shiva Prasad Kollur; Joaquín Ortega-Castro; Juan Frau; Norma Flores-Holguín; Atiyaparveen I Basarikatti; Mallikarjun Chougala; Mrudula Mohan M; Govindappa Banuprakash; Katharigatta N Venugopala; Belakatte P Nandeshwarappa; Ravindra Veerapur; Abdulaziz A Al-Kheraif; Abdallah M Elgorban; Asad Syed; Kiran K Mudnakudu-Nagaraju; Basavaraj Padmashali; Daniel Glossman-Mitnik
Journal:  Molecules       Date:  2021-05-06       Impact factor: 4.411

6.  Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies.

Authors:  Marcos Derita; Iván Montenegro; Francisco Garibotto; Ricardo D Enriz; Mauricio Cuellar Fritis; Susana A Zacchino
Journal:  Molecules       Date:  2013-02-05       Impact factor: 4.411
  6 in total

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