Literature DB >> 18752951

Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones.

Kim M Hutchings1, Tuan P Tran, Edmund L Ellsworth, Brian M Watson, Joseph P Sanchez, H D Showalter, Michael A Stier, Martin Shapiro, E Themis Joannides, Michael Huband, Dai Q Nguyen, Samarendra Maiti, Tingsheng Li, Jyoti Tailor, George Thomas, Chan Ha, Rajeshwar Singh.   

Abstract

A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.

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Year:  2008        PMID： 18752951     DOI： 10.1016/j.bmcl.2008.07.117

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2.

Authors:  R Kirk; A Ratcliffe; G Noonan; M Uosis-Martin; D Lyth; O Bardell-Cox; J Massam; P Schofield; A Lyons; D Clare; J Maclean; A Smith; V Savage; S Mohmed; C Charrier; A-M Salisbury; E Moyo; N Ooi; N Chalam-Judge; J Cheung; N R Stokes; S Best; M Craighead; R Armer; A Huxley
Journal:  RSC Med Chem       Date:  2020-09-18

2.  Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutant strains of Mycobacterium smegmatis.

Authors:  Muhammad Malik; Kevin R Marks; Arkady Mustaev; Xilin Zhao; Kalyan Chavda; Robert J Kerns; Karl Drlica
Journal:  Antimicrob Agents Chemother       Date:  2011-03-07       Impact factor: 5.191

3.  Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.

Authors:  Muhammad Malik; Arkady Mustaev; Heidi A Schwanz; Gan Luan; Nirali Shah; Lisa M Oppegard; Ernane C de Souza; Hiroshi Hiasa; Xilin Zhao; Robert J Kerns; Karl Drlica
Journal:  Nucleic Acids Res       Date:  2016-03-16       Impact factor: 16.971

4.  A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.

Authors:  Thomas Germe; Judit Vörös; Frederic Jeannot; Thomas Taillier; Robert A Stavenger; Eric Bacqué; Anthony Maxwell; Benjamin D Bax
Journal:  Nucleic Acids Res       Date:  2018-05-04       Impact factor: 16.971

Review 5.  Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.

Authors:  Michael A Reiche; Digby F Warner; Valerie Mizrahi
Journal:  Front Mol Biosci       Date:  2017-11-14

Review 6.  Quinolones: action and resistance updated.

Authors:  Karl Drlica; Hiroshi Hiasa; Robert Kerns; Muhammad Malik; Arkady Mustaev; Xilin Zhao
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295
  6 in total

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