| Literature DB >> 18752947 |
Sandeep Sundriyal1, Bhoomi Viswanad, Poduri Ramarao, Asit K Chakraborti, Prasad V Bharatam.
Abstract
A new series of PPARgamma ligands based on barbituric acid (BA) has been designed employing virtual screening and molecular docking approach. To validate the computational approach, designed molecules were synthesized and evaluated in in vitro radioligand binding studies. Out of the total 14 molecules, 6 were found to bind to the murine PPARgamma with IC(50) ranging from 0.1 to 2.5 microM as compared to reference standard, pioglitazone (IC(50)=0.7 microM).Entities:
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Year: 2008 PMID： 18752947 DOI： 10.1016/j.bmcl.2008.08.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823