AIMS: Predicting prostatic cancer patients' outcome is a major objective for clinicians and patients. Several nomograms are currently implemented prior to treatment to help predict clinical and pathological outcome. The aim of this study was to investigate the prognostic significance of morphometric measurements of cancer on the needle biopsy specimen in relation to the final pathological stage or the biochemical failure status following radical prostatectomy, and to determine which measurement of tumour length in cases with discontinuous foci of cancer (DFC) is most reliably reflective of the pathological stage. METHODS AND RESULTS: Of the 100 patients included in this study, 34% had high-stage disease (pT >or= 3 and/or pN1) and 16% experienced biochemical recurrence. The analysis showed that fraction of positive cores, total percentage of cancer and both total and greatest millimetric cancer lengths were the variables most closely associated with pathological stage and biochemical failure status. CONCLUSIONS: This study confirms the prognostic value of recording tumour extent in prostatic needle biopsy reporting. However, the results are inconclusive in determining the best method to record tumour length in cores with DFC and larger studies are needed to answer this question fully.
AIMS: Predicting prostatic cancerpatients' outcome is a major objective for clinicians and patients. Several nomograms are currently implemented prior to treatment to help predict clinical and pathological outcome. The aim of this study was to investigate the prognostic significance of morphometric measurements of cancer on the needle biopsy specimen in relation to the final pathological stage or the biochemical failure status following radical prostatectomy, and to determine which measurement of tumour length in cases with discontinuous foci of cancer (DFC) is most reliably reflective of the pathological stage. METHODS AND RESULTS: Of the 100 patients included in this study, 34% had high-stage disease (pT >or= 3 and/or pN1) and 16% experienced biochemical recurrence. The analysis showed that fraction of positive cores, total percentage of cancer and both total and greatest millimetric cancer lengths were the variables most closely associated with pathological stage and biochemical failure status. CONCLUSIONS: This study confirms the prognostic value of recording tumour extent in prostatic needle biopsy reporting. However, the results are inconclusive in determining the best method to record tumour length in cores with DFC and larger studies are needed to answer this question fully.
Authors: Geoffrey A Sonn; Christopher P Filson; Edward Chang; Shyam Natarajan; Daniel J Margolis; Malu Macairan; Patricia Lieu; Jiaoti Huang; Frederick J Dorey; Robert E Reiter; Leonard S Marks Journal: Urol Oncol Date: 2014-07-11 Impact factor: 3.498
Authors: Maisa M Q Quintal; Luciana R Meirelles; Leandro L L Freitas; Luis A Magna; Ubirajara Ferreira; Athanase Billis Journal: Int Urol Nephrol Date: 2011-02-22 Impact factor: 2.370
Authors: Rodolfo Montironi; Elizabeth H Hammond; Daniel W Lin; John L Gore; John R Srigley; Hema Samaratunga; Lars Egevad; Mark A Rubin; John Nacey; Laurence Klotz; Howard Sandler; Anthony L Zietman; Stuart Holden; Peter A Humphrey; Andrew J Evans; Brett Delahunt; Jesse K McKenney; Daniel Berney; Thomas M Wheeler; Arul Chinnaiyan; Lawrence True; Beatrice Knudsen; Jonathan I Epstein; Mahul B Amin Journal: Virchows Arch Date: 2014-10-16 Impact factor: 4.064
Authors: Chinonyerem Okoro; Arvin K George; M Minhaj Siddiqui; Soroush Rais-Bahrami; Annerleim Walton-Diaz; Nabeel A Shakir; Jason T Rothwax; Dima Raskolnikov; Lambros Stamatakis; Daniel Su; Baris Turkbey; Peter L Choyke; Maria J Merino; Howard L Parnes; Bradford J Wood; Peter A Pinto Journal: J Endourol Date: 2015-07-23 Impact factor: 2.942
Authors: D M Berney; F Algaba; P Camparo; E Compérat; D Griffiths; G Kristiansen; A Lopez-Beltran; R Montironi; M Varma; L Egevad Journal: Virchows Arch Date: 2014-03-04 Impact factor: 4.064