BACKGROUND: Nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain-containing 7 (NLRP7) (pyrin-containing apoptotic protease activating factor-1-like protein 3; PYPAF3, NACHT domain-, leucine-rich repeat, and pyrin domain-containing 7; NALP7) has been thought to contribute to innate immunity and inflammation. Although expression of NLRP7 in human seminoma tissues and several cancer cell lines has been demonstrated, the pathophysiological and prognostic importance in cancer tissues has not been defined. MATERIALS AND METHODS: A series of 70 endometrial cancer cases that had undergone curative resection was studied to determine the correlation between NLRP7 expression and clinico-pathological characteristics in human endometrial cancer tissue. Tissue specimens were evaluated for NLRP7 by immunohistochemistry. RESULTS: NLRP7 expression was positive in cancer cells in 7 cases (10%). There was a statistical relationship between the depth of tumor invasion and NLRP7 expression (p=0.0326). NLRP7 expression showed a trend for being associated with poor prognosis. CONCLUSION: Tumor-produced NLRP7, associated with myometrial invasion, might provide additional prognostic information in endometrial cancer patients.
BACKGROUND: Nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain-containing 7 (NLRP7) (pyrin-containing apoptotic protease activating factor-1-like protein 3; PYPAF3, NACHT domain-, leucine-rich repeat, and pyrin domain-containing 7; NALP7) has been thought to contribute to innate immunity and inflammation. Although expression of NLRP7 in humanseminoma tissues and several cancer cell lines has been demonstrated, the pathophysiological and prognostic importance in cancer tissues has not been defined. MATERIALS AND METHODS: A series of 70 endometrial cancer cases that had undergone curative resection was studied to determine the correlation between NLRP7 expression and clinico-pathological characteristics in humanendometrial cancer tissue. Tissue specimens were evaluated for NLRP7 by immunohistochemistry. RESULTS:NLRP7 expression was positive in cancer cells in 7 cases (10%). There was a statistical relationship between the depth of tumor invasion and NLRP7 expression (p=0.0326). NLRP7 expression showed a trend for being associated with poor prognosis. CONCLUSION:Tumor-produced NLRP7, associated with myometrial invasion, might provide additional prognostic information in endometrial cancerpatients.
Authors: Anderson S Pinheiro; Martina Proell; Clarissa Eibl; Rebecca Page; Robert Schwarzenbacher; Wolfgang Peti Journal: J Biol Chem Date: 2010-06-11 Impact factor: 5.157
Authors: Henriette Poaty; Philippe Coullin; Jean Félix Peko; Philippe Dessen; Ange Lucien Diatta; Alexander Valent; Eric Leguern; Sophie Prévot; Charles Gombé-Mbalawa; Jean-Jacques Candelier; Jean-Yves Picard; Alain Bernheim Journal: PLoS One Date: 2012-01-09 Impact factor: 3.240
Authors: R Bam; S U Venkateshaiah; S Khan; W Ling; S S Randal; X Li; Q Zhang; F van Rhee; B Barlogie; J Epstein; S Yaccoby Journal: Blood Cancer J Date: 2014-08-01 Impact factor: 11.037