M Klepzig1, H Sauer-Eppel, D Jonas, G M Oremek. 1. Department of Laboratory Medicine-Internal Medicine, Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany. martina.klepzig@gmx.de
Abstract
BACKGROUND: The aim of the study was to investigate whether the bone turnover marker procollagen type 1 amino-terminal propeptide (P1NP) could be useful for the early detection of bone metastases in patients with renal cell carcinoma (RCC) and if chemotherapy influences P1NP concentrations in patients with bone metastases. PATIENTS AND METHODS: Serum samples of 36 patients were analyzed using a specific immunoassay. The patients were divided into three groups: 24 patients without metastatic spread, 6 patients with untreated bone metastases and 6 patients who had received sorafenib. RESULTS: The P1NP concentration was significantly higher (p< or =0.001) in the patients with bone metastases (median: 396.10 ng/ml) than in those without bone involvement (median: 35.53 ng/ml). The patients treated with sorafenib showed levels within the normal range (median: 28.96 ng/ml). CONCLUSION: P1NP is a significant diagnostic marker for the development of bone metastases in patients with RCC and could help to evaluate the progress of chemotherapy.
BACKGROUND: The aim of the study was to investigate whether the bone turnover marker procollagen type 1 amino-terminal propeptide (P1NP) could be useful for the early detection of bone metastases in patients with renal cell carcinoma (RCC) and if chemotherapy influences P1NP concentrations in patients with bone metastases. PATIENTS AND METHODS: Serum samples of 36 patients were analyzed using a specific immunoassay. The patients were divided into three groups: 24 patients without metastatic spread, 6 patients with untreated bone metastases and 6 patients who had received sorafenib. RESULTS: The P1NP concentration was significantly higher (p< or =0.001) in the patients with bone metastases (median: 396.10 ng/ml) than in those without bone involvement (median: 35.53 ng/ml). The patients treated with sorafenib showed levels within the normal range (median: 28.96 ng/ml). CONCLUSION: P1NP is a significant diagnostic marker for the development of bone metastases in patients with RCC and could help to evaluate the progress of chemotherapy.
Authors: A Alcaraz; R González-López; J Morote; C de la Piedra; C Meseguer; E Esteban; M Climent; B González-Gragera; J-L Alvarez-Ossorio; I Chirivella; B Mellado; P-C Lara; F Vázquez; J-A Contreras; J Carles; A Murias; V Calderero; J Comet-Batlle; A González-Del Alba; L León-Mateos; A Mañas; J Segarra; A Lassa; C González-Enguita; M-J Méndez; P Samper; M Unda; I Mahillo-Fernández; J Bellmunt Journal: Br J Cancer Date: 2013-06-25 Impact factor: 7.640