| Literature DB >> 1874892 |
G M Rodchenkov1, A N Vedenin, V P Uralets, V A Semenov.
Abstract
Human urinary metabolites of the synthetic corticosteroids prednisone and prednisolone were detected in the course of gas chromatographic steroid profiling as methoxime-trimethylsilyl derivatives. Metabolites were provisionaly identified by combined gas chromatography-mass spectrometry. The major metabolites were 11-keto/11-hydroxy conversion products, 20-hydroxy and 4,5-dihydro analogues of the parent drugs. Cortisone, 6-hydroxy and fully saturated A-ring compounds were minor metabolites. Retention indices and mass spectral data are presented.Entities:
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Year: 1991 PMID： 1874892 DOI： 10.1016/0378-4347(91)80369-n
Source DB: PubMed Journal: J Chromatogr