Literature DB >> 1874889

Determination of 3-hydroxykynurenine in human brain and plasma by high-performance liquid chromatography with electrochemical detection. Increased concentrations in hepatic encephalopathy.

S J Pearson1, G P Reynolds.   

Abstract

A simple and specific method was developed for the determination of 3-hydroxykynurenine in brain tissue and blood plasma using high-performance liquid chromatography with electrochemical detection. This involved an extraction procedure using strong cation-exchange columns and also permitted the determination of 3-hydroxyanthranilic acid in brain tissue. The method was applied to the investigation of post mortem brain tissue from patients with hepatic encephalopathy. Cortical 3-hydroxykynurenine concentrations were substantially increased in such patients above control values, providing evidence for a dysfunction of tryptophan metabolism in this disease.

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Year:  1991        PMID： 1874889     DOI： 10.1016/0378-4347(91)80406-3

Source DB:  PubMed          Journal:  J Chromatogr


  13 in total

1.  Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine.

Authors:  S Okuda; N Nishiyama; H Saito; H Katsuki
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

2.  An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease.

Authors:  S J Pearson; A Meldrum; G P Reynolds
Journal:  J Neural Transm Gen Sect       Date:  1995

3.  Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders.

Authors:  Gregory F Oxenkrug
Journal:  J Neural Transm (Vienna)       Date:  2010-09-02       Impact factor: 3.575

4.  Kynurenines impair energy metabolism in rat cerebral cortex.

Authors:  Patrícia Fernanda Schuck; Anelise Tonin; Gustavo da Costa Ferreira; Carolina Maso Viegas; Alexandra Latini; Clovis Milton Duval Wannmacher; Angela Terezinha de Souza Wyse; Carlos Severo Dutra-Filho; Moacir Wajner
Journal:  Cell Mol Neurobiol       Date:  2006-12-07       Impact factor: 5.046

Review 5.  Tryptophan, adenosine, neurodegeneration and neuroprotection.

Authors:  T W Stone; C M Forrest; G M Mackay; N Stoy; L G Darlington
Journal:  Metab Brain Dis       Date:  2007-12       Impact factor: 3.584

Review 6.  Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.

Authors:  Robert Schwarcz; Paolo Guidetti; Korrapati V Sathyasaikumar; Paul J Muchowski
Journal:  Prog Neurobiol       Date:  2009-04-24       Impact factor: 11.685

7.  The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction.

Authors:  Timur Albayrak; Volker Scherhammer; Nicole Schoenfeld; Erik Braziulis; Thomas Mund; Manuel K A Bauer; Immo E Scheffler; Stefan Grimm
Journal:  Mol Biol Cell       Date:  2003-05-18       Impact factor: 4.138

8.  Creatine and pyruvate prevent behavioral and oxidative stress alterations caused by hypertryptophanemia in rats.

Authors:  Vivian Strassburger Andrade; Denise Bertin Rojas; Lenise Oliveira; Mychely Lopes Nunes; Fernanda Luz de Castro; Cristina Garcia; Tanise Gemelli; Rodrigo Binkowski de Andrade; Clóvis Milton Duval Wannmacher
Journal:  Mol Cell Biochem       Date:  2011-11-12       Impact factor: 3.842

9.  Kynurenine metabolites and migraine: experimental studies and therapeutic perspectives.

Authors:  Annamária Fejes; Arpád Párdutz; József Toldi; László Vécsei
Journal:  Curr Neuropharmacol       Date:  2011-06       Impact factor: 7.363

10.  Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model.

Authors:  Xi Jiang; Lexing Xu; Lin Tang; Fuhe Liu; Ziwei Chen; Jiajia Zhang; Lei Chen; Cong Pang; Xuefeng Yu
Journal:  J Neuroinflammation       Date:  2018-01-04       Impact factor: 8.322
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