| Literature DB >> 1873483 |
M Iwamoto1, T Sakihama, N Kimura, K Tasaka, T Onaya.
Abstract
This study shows that rat thyroid follicular (FRTL5) cells can produce interleukin 6 (IL-6) spontaneously and that IL-1 beta enhanced the production of IL-6 dose-dependently. In addition, 10 ng/mL of IL-1 beta in combination with 10 to 1,000 microU/mL of thyroid-stimulating hormone (TSH) synergistically enhanced IL-6 production. It is suggested that IL-6 released from thyroid follicular cells may be a costimulator of autoreactive B and T cells in autoimmune thyroid disease and may constitute another link between the immune and endocrine systems.Entities:
Mesh：
Substances：
Year: 1991 PMID： 1873483 DOI： 10.1016/1043-4666(91)90504-7
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861