| Literature DB >> 1873207 |
N P Burrows1, M J Walport, A H Hammond, N Davey, R R Jones.
Abstract
A female patient with disfiguring lupus erythematosus profundus (LEP) from the age of 13 years was found to have an isolated partial C4 deficiency, with reduced levels of both allotypes, C4A and C4B. A genetic basis for the hypocomplementaemia was confirmed by a family study of complement and HLA types which revealed heterozygous null alleles for C4A and C4B in the proband. Marked improvement in her cutaneous lesions occurred with thalidomide.Entities:
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Year: 1991 PMID： 1873207 DOI： 10.1111/j.1365-2133.1991.tb06042.x
Source DB: PubMed Journal: Br J Dermatol ISSN： 0007-0963 Impact factor: 9.302