Literature DB >> 1872926

Atherosclerotic plaque caps are locally weakened when macrophages density is increased.

C L Lendon1, M J Davies, G V Born, P D Richardson.   

Abstract

The density of macrophages, identified by the antibody EBMII, in human aortic plaque caps was counted. A contiguous strip of cap tissue was tested mechanically. Aortic plaque caps which had undergone rupture (ulceration) at one end (n = 18) were compared with caps of intact plaques (n = 22). The caps of ruptured plaques showed a significant increase in macrophage density, an increased extensibility and decreased maximum stress (force per unit area) at fracture when compared with caps from intact plaques.

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Year:  1991        PMID： 1872926     DOI： 10.1016/0021-9150(91)90235-u

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  84 in total

1.  Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death.

Authors:  F D Kolodgie; J Narula; A P Burke; N Haider; A Farb; Y Hui-Liang; J Smialek; R Virmani
Journal:  Am J Pathol       Date:  2000-10       Impact factor: 4.307

Review 2.  Therapeutic strategies to deplete macrophages in atherosclerotic plaques.

Authors:  Inge De Meyer; Wim Martinet; Guido R Y De Meyer
Journal:  Br J Clin Pharmacol       Date:  2012-08       Impact factor: 4.335

3.  Characterization of fracture behavior of human atherosclerotic fibrous caps using a miniature single edge notched tensile test.

Authors:  Lindsey A Davis; Samantha E Stewart; Christopher G Carsten; Bruce A Snyder; Michael A Sutton; Susan M Lessner
Journal:  Acta Biomater       Date:  2016-07-16       Impact factor: 8.947

4.  Effect of short-term aspirin use on C-reactive protein.

Authors:  D Feng; R P Tracy; I Lipinska; J Murillo; C McKenna; G H Tofler
Journal:  J Thromb Thrombolysis       Date:  2000-01       Impact factor: 2.300

Review 5.  Targeting the vulnerable plaque: the evolving role of nuclear imaging.

Authors:  John R Davies; James F Rudd; Tim D Fryer; Peter L Weissberg
Journal:  J Nucl Cardiol       Date:  2005 Mar-Apr       Impact factor: 5.952

Review 6.  Optical coherence tomography for imaging the vulnerable plaque.

Authors:  Guillermo J Tearney; Ik-Kyung Jang; Brett E Bouma
Journal:  J Biomed Opt       Date:  2006 Mar-Apr       Impact factor: 3.170

7.  A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps.

Authors:  Yuliya Vengrenyuk; Stéphane Carlier; Savvas Xanthos; Luis Cardoso; Peter Ganatos; Renu Virmani; Shmuel Einav; Lane Gilchrist; Sheldon Weinbaum
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-26       Impact factor: 11.205

8.  Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis.

Authors:  K D O'Brien; M D Allen; T O McDonald; A Chait; J M Harlan; D Fishbein; J McCarty; M Ferguson; K Hudkins; C D Benjamin
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

9.  Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion.

Authors:  J Schneiderman; G M Bordin; I Engelberg; R Adar; D Seiffert; T Thinnes; E F Bernstein; R B Dilley; D J Loskutoff
Journal:  J Clin Invest       Date:  1995-07       Impact factor: 14.808

10.  Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbits.

Authors:  J H Braesen; U Beisiegel; A Niendorf
Journal:  Virchows Arch       Date:  1995       Impact factor: 4.064
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