Literature DB >> 1872854

Lysophosphatidylcholine as a possible second messenger synergistic to diacylglycerol and calcium ion for T-lymphocyte activation.

Y Asaoka1, M Oka, K Yoshida, Y Nishizuka.   

Abstract

An immediate reaction product of phosphatidylcholine hydrolysis catalyzed by phospholipase A2, lysophosphatidylcholine (lysoPC), synergizes with a membrane-permeable diacylglycerol, 1,2-dioctanoylglycerol, and ionomycin to activate resting T-lymphocytes as measured by interleukin-2 alpha-receptor expression. It is suggestive that both phospholipase C and phospholipase A2 are directly involved in signal transduction in a synergistic fashion and that lysoPC acts as an additional second messenger for cellular regulation, probably for long-term responses such as cell proliferation and differentiation.

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Year:  1991        PMID： 1872854     DOI： 10.1016/0006-291x(91)91046-f

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Clinical significance of enzymatic lysophosphatidylcholine (LPC) assay data in patients with sepsis.

Authors:  W H Cho; T Park; Y Y Park; J W Huh; C-M Lim; Y Koh; D-K Song; S-B Hong
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-12-14       Impact factor: 3.267

2.  Role of lysophosphatidylcholine in T-lymphocyte activation: involvement of phospholipase A2 in signal transduction through protein kinase C.

Authors:  Y Asaoka; M Oka; K Yoshida; Y Sasaki; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

3.  Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction.

Authors:  L Arbibe; K Koumanov; D Vial; C Rougeot; G Faure; N Havet; S Longacre; B B Vargaftig; G Béréziat; D R Voelker; C Wolf; L Touqui
Journal:  J Clin Invest       Date:  1998-09-15       Impact factor: 14.808

4.  Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.

Authors:  H Aihara; Y Asaoka; K Yoshida; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

5.  Purification and properties of lysophospholipase isoenzymes from pig gastric mucosa.

Authors:  H Sunaga; H Sugimoto; Y Nagamachi; S Yamashita
Journal:  Biochem J       Date:  1995-06-01       Impact factor: 3.857

6.  Lysophosphatidylcholine: a chemoattractant to human T lymphocytes.

Authors:  A K Ryborg; B Deleuran; K Thestrup-Pedersen; K Kragballe
Journal:  Arch Dermatol Res       Date:  1994       Impact factor: 3.017

7.  Full-Length cDNA Cloning, Molecular Characterization and Differential Expression Analysis of Lysophospholipase I from Ovis aries.

Authors:  Nan-Nan Liu; Zeng-Shan Liu; Pan Hu; Ying Zhang; Shi-Ying Lu; Yan-Song Li; Yong-Jie Yang; Dong-Song Zhang; Yu Zhou; Hong-Lin Ren
Journal:  Int J Mol Sci       Date:  2016-07-28       Impact factor: 5.923

8.  Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung.

Authors:  Sydney E Dautel; Jennifer E Kyle; Geremy Clair; Ryan L Sontag; Karl K Weitz; Anil K Shukla; Son N Nguyen; Young-Mo Kim; Erika M Zink; Teresa Luders; Charles W Frevert; Sina A Gharib; Julia Laskin; James P Carson; Thomas O Metz; Richard A Corley; Charles Ansong
Journal:  Sci Rep       Date:  2017-02-01       Impact factor: 4.379

9.  Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts.

Authors:  N N Desai; R O Carlson; M E Mattie; A Olivera; N E Buckley; T Seki; G Brooker; S Spiegel
Journal:  J Cell Biol       Date:  1993-06       Impact factor: 10.539
  9 in total

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