Literature DB >> 18728390

PI3-K and GSK-3: Akt-ing together with microtubules.

Graham J Buttrick1, James G Wakefield.   

Abstract

Phosphoinositide-3-Kinase (PI3-K) and the downstream kinases Akt and Glycogen Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule (MT) dynamics and organization. Here we review the role of this signalling pathway in controlling MTs, and explore ways in which the kinases and their substrates may co-operate to spatially regulate MTs in different contexts.

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Year:  2008        PMID： 18728390     DOI： 10.4161/cc.7.17.6514

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  29 in total

1.  Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer.

Authors:  Sherry X Yang; Joseph P Costantino; Chungyeul Kim; Eleftherios P Mamounas; Dat Nguyen; Jong-Hyeon Jeong; Norman Wolmark; Kelley Kidwell; Soonmyung Paik; Sandra M Swain
Journal:  J Clin Oncol       Date:  2010-05-17       Impact factor: 44.544

2.  The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents.

Authors:  Séverine Celton-Morizur; Grégory Merlen; Dominique Couton; Germain Margall-Ducos; Chantal Desdouets
Journal:  J Clin Invest       Date:  2009-07       Impact factor: 14.808

3.  The focal adhesion protein kindlin-2 controls mitotic spindle assembly by inhibiting histone deacetylase 6 and maintaining α-tubulin acetylation.

Authors:  Hui-Foon Tan; Suet-Mien Tan
Journal:  J Biol Chem       Date:  2020-03-13       Impact factor: 5.157

4.  The novel PI3K-δ inhibitor TGR-1202 enhances Brentuximab Vedotin-induced Hodgkin lymphoma cell death via mitotic arrest.

Authors:  S L Locatelli; G Careddu; G Inghirami; L Castagna; P Sportelli; A Santoro; C Carlo-Stella
Journal:  Leukemia       Date:  2016-08-08       Impact factor: 11.528

5.  Klebsiella pneumoniae translocates across the intestinal epithelium via Rho GTPase- and phosphatidylinositol 3-kinase/Akt-dependent cell invasion.

Authors:  Chun-Ru Hsu; Yi-Jiun Pan; Ju-Yun Liu; Chun-Tang Chen; Tzu-Lung Lin; Jin-Town Wang
Journal:  Infect Immun       Date:  2014-12-01       Impact factor: 3.441

6.  The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells.

Authors:  Javier Oviedo-Boyso; Ricarda Cortés-Vieyra; Alejandro Huante-Mendoza; Hong B Yu; Juan J Valdez-Alarcón; Alejandro Bravo-Patiño; Marcos Cajero-Juárez; B Brett Finlay; Víctor M Baizabal-Aguirre
Journal:  Infect Immun       Date:  2011-08-15       Impact factor: 3.441

Review 7.  GSK3: a multifaceted kinase in Wnt signaling.

Authors:  Dianqing Wu; Weijun Pan
Journal:  Trends Biochem Sci       Date:  2009-10-31       Impact factor: 13.807

8.  Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication.

Authors:  Jamária A P Soares; Flávia G G Leite; Luciana G Andrade; Alice A Torres; Lirlândia P De Sousa; Lucíola S Barcelos; Mauro M Teixeira; Paulo C P Ferreira; Erna G Kroon; Thaís Souto-Padrón; Cláudio A Bonjardim
Journal:  J Virol       Date:  2009-04-22       Impact factor: 5.103

Review 9.  Manganese superoxide dismutase regulates a redox cycle within the cell cycle.

Authors:  Ehab H Sarsour; Amanda L Kalen; Prabhat C Goswami
Journal:  Antioxid Redox Signal       Date:  2013-05-29       Impact factor: 8.401

10.  Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration.

Authors:  Dannis G van Vuurden; Eleonora Aronica; Esther Hulleman; Laurine E Wedekind; Dennis Biesmans; Arjan Malekzadeh; Marianna Bugiani; Dirk Geerts; David P Noske; W Peter Vandertop; Gertjan J L Kaspers; Jacqueline Cloos; Thomas Würdinger; Petra P M van der Stoop
Journal:  Neuro Oncol       Date:  2014-07       Impact factor: 12.300
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