Literature DB >> 1872800

Effect of magnesium ions on the inhibition of S-adenosylmethionine decarboxylase from Escherichia coli by [2-(amino-oxy)ethyl](5'-deoxyadenosin-5'-yl)(methyl)sulphonium .

E L Weitkamp1, H B Dixon, A R Khomutov, R M Khomutov.   

Abstract

[2-(Amino-oxy)ethyl](5'-deoxyadenosin-5'-yl)(methyl)sulphonium+ ++, the amino-oxy analogue of decarboxylated S-adenosylmethionine, is a potent irreversible inhibitor of Escherichia coli S-adenosylmethionine decarboxylase [Khomutov, Zavalova, Syrku, Artamonova & Khomutov (1983) Bioorg. Khim. 9, 130-131; Artamonova, Zavalova, Khomutov & Khomutov (1986) Bioorg. Khim. 12, 206-212]. We have shown that Mg2+ ions are required for the irreversible inhibition of the decarboxylase, and that S-adenosylmethionine protects against this inhibition.

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Year:  1991        PMID： 1872800      PMCID： PMC1151290          DOI： 10.1042/bj2770643

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  7 in total

1.  Effect of inhibitors of S-adenosylmethionine decarboxylase on polyamine content and growth of L1210 cells.

Authors:  A E Pegg; D B Jones; J A Secrist
Journal:  Biochemistry       Date:  1988-03-08       Impact factor: 3.162

2.  Purification of adenosylmethionine decarboxylase from Escherichia coli W: evidence for covalently bound pyruvate.

Authors:  R B Wickner; C W Tabor; H Tabor
Journal:  J Biol Chem       Date:  1970-04-25       Impact factor: 5.157

3.  Mechanism of substrate inactivation of Escherichia coli S-adenosylmethionine decarboxylase.

Authors:  D L Anton; R Kutny
Journal:  Biochemistry       Date:  1987-10-06       Impact factor: 3.162

4.  Complexes of aspartate aminotransferase with hydroxylamine derivatives: spectral studies in solution and in the crystalline state.

Authors:  L T Delbaere; J Kallen; Z Markovic-Housley; A R Khomutov; R M Khomutov; M Y Karpeisky; J N Jansonius
Journal:  Biochimie       Date:  1989-04       Impact factor: 4.079

5.  S-adenosylmethionine decarboxylase of Escherichia coli. Studies on the covalently linked pyruvate required for activity.

Authors:  G D Markham; C W Tabor; H Tabor
Journal:  J Biol Chem       Date:  1982-10-25       Impact factor: 5.157

6.  Cellular characterization of a new irreversible inhibitor of S-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of L1210 cells.

Authors:  D L Kramer; R M Khomutov; Y V Bukin; A R Khomutov; C W Porter
Journal:  Biochem J       Date:  1989-04-15       Impact factor: 3.857

7.  [An effective inhibitor of S-adenosylmethionine decarboxylase].

Authors:  R M Khomutov; L L Zavalova; V I Syrku; E Iu Artamonova; A R Khomutov
Journal:  Bioorg Khim       Date:  1983-01
  7 in total

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