BACKGROUND: In this study, we evaluated the feasibility and clinical usefulness of TS(E-E(') ), the time interval between the onsets of early diastolic mitral inflow velocity (E) and mitral annular velocity (E'), obtained by simultaneously tracing E and E', in terms of evaluating diastolic function. METHODS: By the diastolic functional status, 105 patients were allocated to abnormal relaxation, pseudonormal filling (PN), or normal diastolic function groups (n = 30, 43, and 32, respectively). The TS(E-E(') ) was measured in the same cardiac cycle by the pulsed-wave Doppler (PWD) tracing of mitral inflow near the septal annulus with appropriate filter and gain settings. RESULTS: TS(E-E(') ) was prolonged in the PN group versus the normal group (34.1 +/- 12.2 msec versus 12.1 +/- 8.5 msec, p< or =0.001). The area under the receiver operating characteristic curve of TS(E-E(') ) for the detection of PN was 0.91 (95% confidence interval [CI]; 0.85 approximately 0.97, p<0.001), and 24.0 msec was determined to be the optimal cut-off value (specificity 83.7%, sensitivity 90.3%). CONCLUSION: Simultaneous measurement of TS(E-E(') ) is feasible and clinically applicable for the grading of diastolic dysfunction (DD).
BACKGROUND: In this study, we evaluated the feasibility and clinical usefulness of TS(E-E(') ), the time interval between the onsets of early diastolic mitral inflow velocity (E) and mitral annular velocity (E'), obtained by simultaneously tracing E and E', in terms of evaluating diastolic function. METHODS: By the diastolic functional status, 105 patients were allocated to abnormal relaxation, pseudonormal filling (PN), or normal diastolic function groups (n = 30, 43, and 32, respectively). The TS(E-E(') ) was measured in the same cardiac cycle by the pulsed-wave Doppler (PWD) tracing of mitral inflow near the septal annulus with appropriate filter and gain settings. RESULTS: TS(E-E(') ) was prolonged in the PN group versus the normal group (34.1 +/- 12.2 msec versus 12.1 +/- 8.5 msec, p< or =0.001). The area under the receiver operating characteristic curve of TS(E-E(') ) for the detection of PN was 0.91 (95% confidence interval [CI]; 0.85 approximately 0.97, p<0.001), and 24.0 msec was determined to be the optimal cut-off value (specificity 83.7%, sensitivity 90.3%). CONCLUSION: Simultaneous measurement of TS(E-E(') ) is feasible and clinically applicable for the grading of diastolic dysfunction (DD).
Authors: Jacob E Moller; Graham S Hillis; Jae K Oh; James B Seward; Guy S Reeder; R Scott Wright; Seung W Park; Kent R Bailey; Patricia A Pellikka Journal: Circulation Date: 2003-04-14 Impact factor: 29.690
Authors: Allison M Pritchett; Douglas W Mahoney; Steven J Jacobsen; Richard J Rodeheffer; Barry L Karon; Margaret M Redfield Journal: J Am Coll Cardiol Date: 2005-01-04 Impact factor: 24.094
Authors: Carlos Rivas-Gotz; Dirar S Khoury; Michael Manolios; Liyun Rao; Helen A Kopelen; Sherif F Nagueh Journal: J Am Coll Cardiol Date: 2003-10-15 Impact factor: 24.094
Authors: Margaret M Redfield; Steven J Jacobsen; John C Burnett; Douglas W Mahoney; Kent R Bailey; Richard J Rodeheffer Journal: JAMA Date: 2003-01-08 Impact factor: 56.272
Authors: Allison M Pritchett; Steven J Jacobsen; Douglas W Mahoney; Richard J Rodeheffer; Kent R Bailey; Margaret M Redfield Journal: J Am Coll Cardiol Date: 2003-03-19 Impact factor: 24.094