Literature DB >> 18726578

Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines.

Brendon Y Chua1, Weiguang Zeng, David C Jackson.   

Abstract

Effective Th1- and Th2-type immune responses that result in protective immunity against pathogens can be induced by self-adjuvanting lipopeptides containing the lipid moiety dipalmitoyl-S-glyceryl cysteine (Pam2Cys). The potent immunogenicity of these lipopeptides is due to their ability to activate dendritic cells by targeting and signaling through Toll-like receptor-2 (TLR-2). In addition, the simplicity and flexibility in their design as well as their ease of chemical definition and characterisation makes them highly attractive vaccine candidates for humans and animals. We describe in this chapter the techniques involved in the synthesis of an immunocontraceptive lipopeptide vaccine as well as the experimental assays carried out to evaluate its efficiency.

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Year:  2008        PMID： 18726578     DOI： 10.1007/978-1-59745-419-3_14

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  10 in total

1.  Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model.

Authors:  Brendon Y Chua; Timothy P Stinear; Kirstie M Mangas; Andrew H Buultjens; Jessica L Porter; Sarah L Baines; Estelle Marion; Laurent Marsollier; Nicholas J Tobias; Sacha J Pidot; Kylie M Quinn; David J Price; Katherine Kedzierska; Weiguang Zeng; David C Jackson
Journal:  Infect Immun       Date:  2020-02-20       Impact factor: 3.441

2.  Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-γ and reduces parasite burden in HLA-B*0702 mice.

Authors:  Hua Cong; Ernest J Mui; William H Witola; John Sidney; Jeff Alexander; Alessandro Sette; Ajesh Maewal; Kamal El Bissati; Ying Zhou; Yasuhiro Suzuki; Daniel Lee; Stuart Woods; Caroline Sommerville; Fiona L Henriquez; Craig W Roberts; Rima McLeod
Journal:  Hum Immunol       Date:  2011-10-12       Impact factor: 2.850

3.  Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CD8+T cell epitope based, adjuvanted vaccine protective against Toxoplasma gondii.

Authors:  Hua Cong; Ernest J Mui; William H Witola; John Sidney; Jeff Alexander; Alessandro Sette; Ajesh Maewal; Rima McLeod
Journal:  Immunome Res       Date:  2010-12-03

4.  Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides.

Authors:  Simona Gallorini; Francesco Berti; Giuseppe Mancuso; Roberta Cozzi; Marco Tortoli; Gianfranco Volpini; John L Telford; Concetta Beninati; Domenico Maione; Andreas Wack
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-29       Impact factor: 11.205

5.  Toll-like receptors in autoimmunity with special reference to systemic lupus erythematosus.

Authors:  Vandana D Pradhan; Swaptagni Das; Prathamesh Surve; Kanjaksha Ghosh
Journal:  Indian J Hum Genet       Date:  2012-05

6.  Lipid motif of a bacterial antigen mediates immune responses via TLR2 signaling.

Authors:  Amit A Lugade; Anna Bianchi-Smiraglia; Vandana Pradhan; Galina Elkin; Timothy F Murphy; Yasmin Thanavala
Journal:  PLoS One       Date:  2011-05-17       Impact factor: 3.240

7.  Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines.

Authors:  Waleed M Hussein; Tzu-Yu Liu; Pirashanthini Maruthayanar; Saori Mukaida; Peter M Moyle; James W Wells; Istvan Toth; Mariusz Skwarczynski
Journal:  Chem Sci       Date:  2016-01-04       Impact factor: 9.825

Review 8.  TLR Agonists as Modulators of the Innate Immune Response and Their Potential as Agents Against Infectious Disease.

Authors:  Edin J Mifsud; Amabel C L Tan; David C Jackson
Journal:  Front Immunol       Date:  2014-03-03       Impact factor: 7.561

9.  Understanding CD8+ T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope.

Authors:  Thi Ho Nguyen; Amabel Cl Tan; Sue D Xiang; Anne Goubier; Kim L Harland; E Bridie Clemens; Magdalena Plebanski; Katherine Kedzierska
Journal:  Clin Transl Immunology       Date:  2017-03-17

10.  Targeting Toll-Like Receptor 2: Polarization of Porcine Macrophages by a Mycoplasma-Derived Pam2cys Lipopeptide.

Authors:  Giulia Franzoni; Antonio Anfossi; Chiara Grazia De Ciucis; Samanta Mecocci; Tania Carta; Silvia Dei Giudici; Floriana Fruscione; Susanna Zinellu; Guendalina Vito; Simon Paul Graham; Annalisa Oggiano; Bernardo Chessa; Elisabetta Razzuoli
Journal:  Vaccines (Basel)       Date:  2021-06-23
  10 in total

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