Literature DB >> 18723131

Transcriptional regulation of IL-2 in health and autoimmunity.

José C Crispín1, George C Tsokos.   

Abstract

The regulation of IL-2 production is central to our understanding of the immune system. Key during T cell activation, it also plays an essential role in the regulation of the immune response. This review discusses the function of recently described factors that modulate transcription and chromatin remodeling at the IL2 promoter. Also, it addresses the role of FoxP3 as a transcriptional regulator in conventional T cells and regulatory T cells, and the mechanisms whereby CD28 stabilizes IL2 transcription and translation. Finally, the alterations that prevent T cells from SLE patients from producing normal amounts of IL-2 upon stimulation are described.

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Year:  2008        PMID： 18723131      PMCID： PMC2655130          DOI： 10.1016/j.autrev.2008.07.042

Source DB:  PubMed          Journal:  Autoimmun Rev        ISSN： 1568-9972            Impact factor:   9.754


  40 in total

1.  Signals from CD28 induce stable epigenetic modification of the IL-2 promoter.

Authors:  Rajan M Thomas; Ling Gao; Andrew D Wells
Journal:  J Immunol       Date:  2005-04-15       Impact factor: 5.422

2.  The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism.

Authors:  Klaus Tenbrock; Yuang-Taung Juang; Mate Tolnay; George C Tsokos
Journal:  J Immunol       Date:  2003-03-15       Impact factor: 5.422

3.  Antisense cyclic adenosine 5'-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus.

Authors:  Klaus Tenbrock; Yuang-Taung Juang; Mark F Gourley; Madhusoodana P Nambiar; George C Tsokos
Journal:  J Immunol       Date:  2002-10-15       Impact factor: 5.422

4.  CD28-costimulation activates cyclic AMP-responsive element-binding protein in T lymphocytes.

Authors:  Y P Hsueh; H E Liang; S Y Ng; M Z Lai
Journal:  J Immunol       Date:  1997-01-01       Impact factor: 5.422

5.  Cyclic adenosine 5'-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus.

Authors:  Vasileios C Kyttaris; Yuang-Taung Juang; Klaus Tenbrock; Arthur Weinstein; George C Tsokos
Journal:  J Immunol       Date:  2004-09-01       Impact factor: 5.422

6.  Myocyte enhancer factor 2 mediates calcium-dependent transcription of the interleukin-2 gene in T lymphocytes: a calcium signaling module that is distinct from but collaborates with the nuclear factor of activated T cells (NFAT).

Authors:  Fan Pan; Zhaohui Ye; Linzhao Cheng; Jun O Liu
Journal:  J Biol Chem       Date:  2004-01-13       Impact factor: 5.157

7.  Transcriptional mechanisms underlying lymphocyte tolerance.

Authors:  Fernando Macián; Francisco García-Cózar; Sin-Hyeog Im; Heidi F Horton; Michael C Byrne; Anjana Rao
Journal:  Cell       Date:  2002-06-14       Impact factor: 41.582

8.  Octamer factors exert a dual effect on the IL-2 and IL-4 promoters.

Authors:  I Pfeuffer; S Klein-Hessling; A Heinfling; S Chuvpilo; C Escher; T Brabletz; B Hentsch; H Schwarzenbach; P Matthias; E Serfling
Journal:  J Immunol       Date:  1994-12-15       Impact factor: 5.422

9.  A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1.

Authors:  C Skerka; E L Decker; P F Zipfel
Journal:  J Biol Chem       Date:  1995-09-22       Impact factor: 5.157

10.  Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization.

Authors:  Ruka Setoguchi; Shohei Hori; Takeshi Takahashi; Shimon Sakaguchi
Journal:  J Exp Med       Date:  2005-03-07       Impact factor: 14.307
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  44 in total

1.  Integration of MicroRNA databases to study MicroRNAs associated with multiple sclerosis.

Authors:  Charlotte Angerstein; Michael Hecker; Brigitte Katrin Paap; Dirk Koczan; Madhan Thamilarasan; Hans-Jürgen Thiesen; Uwe Klaus Zettl
Journal:  Mol Neurobiol       Date:  2012-05-02       Impact factor: 5.590

2.  Estrogen upregulates cyclic AMP response element modulator α expression and downregulates interleukin-2 production by human T lymphocytes.

Authors:  Vaishali R Moulton; Dana R Holcomb; Melissa C Zajdel; George C Tsokos
Journal:  Mol Med       Date:  2012-05-09       Impact factor: 6.354

3.  TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.

Authors:  Dalia E Gaddis; Suzanne M Michalek; Jannet Katz
Journal:  J Immunol       Date:  2011-04-15       Impact factor: 5.422

4.  A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus.

Authors:  Thomas Rauen; Konrad Benedyk; Yuang-Taung Juang; Claus Kerkhoff; Vasileios C Kyttaris; Johannes Roth; George C Tsokos; Klaus Tenbrock
Journal:  J Biol Chem       Date:  2011-07-13       Impact factor: 5.157

Review 5.  Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases.

Authors:  Christian M Hedrich; George C Tsokos
Journal:  Trends Mol Med       Date:  2011-08-30       Impact factor: 11.951

6.  The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.

Authors:  Beixue Gao; Qingfei Kong; Yana Zhang; Chawon Yun; Sharon Y R Dent; Jianxun Song; Donna D Zhang; Yiming Wang; Xuemei Li; Deyu Fang
Journal:  J Immunol       Date:  2017-04-19       Impact factor: 5.422

7.  Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis.

Authors:  Dalia E Gaddis; Craig L Maynard; Casey T Weaver; Suzanne M Michalek; Jannet Katz
Journal:  J Leukoc Biol       Date:  2012-10-17       Impact factor: 4.962

8.  Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity.

Authors:  Li Zhang; Anne M Bertucci; Rosalind Ramsey-Goldman; Elizabeth Randall Harsha-Strong; Richard K Burt; Syamal K Datta
Journal:  Clin Immunol       Date:  2013-08-23       Impact factor: 3.969

Review 9.  Malt1 and cIAP2-Malt1 as effectors of NF-kappaB activation: kissing cousins or distant relatives?

Authors:  Lara M Kingeter; Brian C Schaefer
Journal:  Cell Signal       Date:  2009-09-19       Impact factor: 4.315

Review 10.  MicroRNAs--novel regulators of systemic lupus erythematosus pathogenesis.

Authors:  Nan Shen; Dong Liang; Yuanjia Tang; Niek de Vries; Paul-Peter Tak
Journal:  Nat Rev Rheumatol       Date:  2012-10-16       Impact factor: 20.543
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