| Literature DB >> 18723007 |
Federico Buonanno1, Luana Quassinti, Massimo Bramucci, Consuelo Amantini, Roberta Lucciarini, Giorgio Santoni, Hideo Iio, Claudio Ortenzi.
Abstract
Climacostol (5-(Z)-non-2-enyl-benzene-1,3-diol) is a natural toxin isolated from the freshwater ciliated protozoan Climacostomum virens and belongs to the group of resorcinolic lipids, compounds that show antimicrobial, antiparasitic and antitumor activities. We investigated the cytotoxic activity of the chemically synthesized toxin on: (1) human tumor squamous carcinoma A431 cells, (2) human promyelocytic leukaemia HL60 cells, and (3) human non-tumor endothelial EA.hy926 cells. The results showed that climacostol effectively inhibited the growth of tumor cell lines in a dose-dependent manner by inducing programmed cell death, with non-tumor cells proving significantly more resistant to the toxin.Entities:
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Year: 2008 PMID： 18723007 DOI： 10.1016/j.cbi.2008.07.007
Source DB: PubMed Journal: Chem Biol Interact ISSN： 0009-2797 Impact factor: 5.192