| Literature DB >> 18722772 |
Barry G Shearer1, Hari S Patel, Andrew N Billin, James M Way, Deborah A Winegar, Millard H Lambert, Robert X Xu, Lisa M Leesnitzer, Raymond V Merrihew, Stephane Huet, Timothy M Willson.
Abstract
Anthranilic acid GW9371 was identified as a novel class of PPARdelta partial agonist through high-throughput screening. The design and synthesis of SAR analogues is described. GSK1115 and GSK7227 show potent partial agonism of the PPARdelta target genes CPT1a and PDK4 in skeletal muscle cells.Entities:
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Year: 2008 PMID： 18722772 DOI： 10.1016/j.bmcl.2008.08.011
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823