Literature DB >> 18722036

Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives.

Govindasami Periyasami1, Raghavachary Raghunathan, Gangadharan Surendiran, Narayanasamy Mathivanan.   

Abstract

A series of novel dispiropyrrolidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from sarcosin and di/tri ketone with the dipolarophile (E)-2-arylidine-1-keto-carbazoles. The cycloadducts ketocarbazalo spiro N-methyl pyrrolidines showed the most interesting antimicrobial activity at lower concentration.

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Year:  2008        PMID： 18722036     DOI： 10.1016/j.ejmech.2008.07.009

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  3 in total

1.  5-[(E)-Benzyl-idene]-2-hy-droxy-10-methyl-8-phenyl-3,10-diazahexa-cyclo-[10.7.1.1.0.0.0]henicosa-1(19),12(20),13,15,17-pentaen-6-one ethanol 0.25-solvate 0.6-hydrate.

Authors:  Raju Suresh Kumar; Hasnah Osman; Subbu Perumal; Madhukar Hemamalini; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-09

2.  (E)-2-(Furan-2-yl-methyl-idene)-8-methyl-2,3,4,9-tetra-hydro-1H-carbazol-1-one.

Authors:  R Archana; E Yamuna; K J Rajendra Prasad; A Thiruvalluvar; R J Butcher
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-11-13

3.  Base mediated spirocyclization of quinazoline: one-step synthesis of spiro-isoindolinone dihydroquinazolinones.

Authors:  Rapolu Venkateshwarlu; V Narayana Murthy; Krishnaji Tadiparthi; Satish P Nikumbh; Rajesh Jinkala; Vidavalur Siddaiah; M V Madhu Babu; Hindupur Rama Mohan; Akula Raghunadh
Journal:  RSC Adv       Date:  2020-03-04       Impact factor: 4.036
  3 in total

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