Literature DB >> 18721058

Expression of the dengue virus type 2 NS5 protein in a CD4(+) T cell line inhibits HIV replication.

James H McLinden1, Jack T Stapleton, Qing Chang, Jinhua Xiang.   

Abstract

Human immunodeficiency virus (HIV) load is suppressed during dengue virus infection. The NS5A phosphoprotein of GB virus C (a related flavivirus) inhibits HIV replication in vitro. To determine whether the dengue virus NS5 protein inhibits HIV replication, CD4(+) T cell lines expressing this protein were generated. HIV replication in dengue virus NS5-expressing cells decreased by >90% compared with control cells (P < .01), and this was mediated in part by decreased HIV coreceptor (CXCR4) expression and increased production of SDF-1. Thus, the dengue virus NS5 protein inhibits HIV replication in vitro, potentially explaining the reduction in HIV load observed during acute dengue virus infection.

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Year:  2008        PMID： 18721058     DOI： 10.1086/591254

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  9 in total

1.  Dengue virus serotype 1 non-structural protein NS5 expression interferes with HIV replication in a CD4+ T-cell line.

Authors:  Uriel A López-Lemus; Clemente Vásquez; Roberto Vázquez-Campuzano; Salvador Valle-Reyes; Carmen Guzmán-Bracho; Diego Araiza-Garaygordobil; Nicte Rebolledo-Prudencio; Iván Delgado-Enciso; Francisco Espinoza-Gómez
Journal:  Am J Trop Med Hyg       Date:  2014-01-27       Impact factor: 2.345

Review 2.  GBV-C: state of the art and future prospects.

Authors:  Maria Teresa Maidana Giret; Esper Georges Kallas
Journal:  Curr HIV/AIDS Rep       Date:  2012-03       Impact factor: 5.071

3.  Dengue Infection in a Human Immunodeficiency Virus-1 Positive Patient Chronically Infected with Hepatitis B Virus in Western Mexico.

Authors:  Iván Delgado-Enciso; Francisco Espinoza-Gómez; Rodolfo Ochoa-Jiménez; Salvador Valle-Reyes; Clemente Vásquez; Uriel A López-Lemus
Journal:  Am J Trop Med Hyg       Date:  2016-11-28       Impact factor: 2.345

4.  Dengue Virus Coinfection in Human Immunodeficiency Virus-1-Infected Patients on the West Coast of Mexico.

Authors:  Francisco Espinoza-Gómez; Iván Delgado-Enciso; Salvador Valle-Reyes; Rodolfo Ochoa-Jiménez; Conrado Arechiga-Ramírez; José L Gámez-Arroyo; Roberto Vázquez-Campuzano; Carmen Guzmán-Bracho; Clemente Vásquez; Uriel A López-Lemus
Journal:  Am J Trop Med Hyg       Date:  2017-07-19       Impact factor: 2.345

Review 5.  Coinfecting viruses as determinants of HIV disease.

Authors:  Andrea Lisco; Christophe Vanpouille; Leonid Margolis
Journal:  Curr HIV/AIDS Rep       Date:  2009-02       Impact factor: 5.071

6.  Viruses within the Flaviviridae decrease CD4 expression and inhibit HIV replication in human CD4+ cells.

Authors:  Jinhua Xiang; James H McLinden; Robert A Rydze; Qing Chang; Thomas M Kaufman; Donna Klinzman; Jack T Stapleton
Journal:  J Immunol       Date:  2009-12-15       Impact factor: 5.422

7.  Differential clinical outcome of dengue infection among patients with and without HIV infection: a matched case-control study.

Authors:  Junxiong Pang; Tun-Linn Thein; David C Lye; Yee-Sin Leo
Journal:  Am J Trop Med Hyg       Date:  2015-03-30       Impact factor: 2.345

8.  Survey of malaria and anti-dengue virus IgG among febrile HIV-infected patients attending a tertiary hospital in Abuja, Nigeria.

Authors:  Jelili Olaide Mustapha; Anthony Uchenna Emeribe; Idris Abdullahi Nasir
Journal:  HIV AIDS (Auckl)       Date:  2017-06-30

9.  T Cell Responses to Nonstructural Protein 3 Distinguish Infections by Dengue and Zika Viruses.

Authors:  Bobby Brooke Herrera; Wen-Yang Tsai; Carlos Brites; Estela Luz; Celia Pedroso; Jan Felix Drexler; Wei-Kung Wang; Phyllis J Kanki
Journal:  mBio       Date:  2018-08-07       Impact factor: 7.867
  9 in total

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