Literature DB >> 187207

Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.

M A Wainberg, V Deutsch, D W Weiss.   

Abstract

The immunoprophylactic effects of the methanol extraction residue (MER) of BCG were investigated in Strain 2 guinea-pigs injected with cells of the transplantable, diethylnitrosamine-induced, Line 10 hepatocarcinoma. Pretreatment with MER at times ranging from 18 to 182 days prior to tumour implantation protected approximately 40% of guinea-pigs from progressive neoplastic disease. In addition, MER-treated animals developed specific cell-mediated anti-tumour immunity both more rapidly and at higher levels than did non-MER-treated tumour-bearing controls. It was not possible, however, to prognosticate from the results of such laboratory studies to the outcome of immunoprophylaxis.

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Year:  1976        PMID： 187207      PMCID： PMC2025198          DOI： 10.1038/bjc.1976.204

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  24 in total

1.  Protection against guinea pig hepatomas by pretreatment with subcelluar fractions of Mycobacterium bovis (BCG).

Authors:  P Minden; M Wainberg; D W Weiss
Journal:  J Natl Cancer Inst       Date:  1974-05       Impact factor: 13.506

2.  Effect of treatment of C57BL-6 mice with the methanol extraction residue fraction of BCG on leukemogenesis induced by the radiation leukemia virus.

Authors:  N Haran-Ghera; D W Weiss
Journal:  J Natl Cancer Inst       Date:  1973-01       Impact factor: 13.506

3.  Stimulating influence of bacillus Calmette-Guérin on immunity to polyoma tumors and spontaneous leukemia.

Authors:  P Lemonde; R Dubreuil; A Guindon; G Lussier
Journal:  J Natl Cancer Inst       Date:  1971-11       Impact factor: 13.506

4.  Suppression of tumor growth at the site of infection with living Bacillus Calmette-Guérin.

Authors:  B Zbar; I D Bernstein; H J Rapp
Journal:  J Natl Cancer Inst       Date:  1971-04       Impact factor: 13.506

5.  Transplantable hepatomas induced in strain-2 guinea pigs by diethylnitrosamine: characterization by histology, growth, and chromosomes.

Authors:  B Zbar; H T Wepsic; H J Rapp; J Whang-Peng
Journal:  J Natl Cancer Inst       Date:  1969-10       Impact factor: 13.506

6.  Shared antigens between Mycobacterium bovis (BCG) and neoplastic cells.

Authors:  P Minden; J K McClatchy; M Wainberg; D W Weiss
Journal:  J Natl Cancer Inst       Date:  1974-11       Impact factor: 13.506

7.  Potentiation and modulation of the immune response of guinea pigs to poorly immunogenic protein-hapten conjugates by pretreatment with the MER fraction of attenuated tubercle bacilli.

Authors:  S Ben-Efraim; M Constantini-Sourojon; D W Weiss
Journal:  Cell Immunol       Date:  1973-06       Impact factor: 4.868

8.  Prevention of tumor growth after intradermal injection of BCG extracts: a comparison of results in strain-2 guinea pigs from the National Institutes of Health and from the National Jewish Hospital and Research Center.

Authors:  B Zbar; P Minden; J K McClatchy; H J Rapp
Journal:  J Natl Cancer Inst       Date:  1976-02       Impact factor: 13.506

9.  Immunotherapy of cancer: regression of tumors after intralesional injection of living Mycobacterium bovis.

Authors:  B Zbar; T Tanaka
Journal:  Science       Date:  1971-04-16       Impact factor: 47.728

10.  Active immunotherapy of L1210 leukaemia applied after the graft of tumour cells.

Authors:  G Mathé; P Pouillart; F Lapeyraque
Journal:  Br J Cancer       Date:  1969-12       Impact factor: 7.640
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  1 in total

1.  Enhancement of avian sarcoma virus-induced tumor growth after pretreatment with BCG.

Authors:  M A Wainberg; E Israel
Journal:  Infect Immun       Date:  1978-11       Impact factor: 3.441
  1 in total

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