Literature DB >> 18720392

Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.

Charles E Thompson1, Fletcher B Taylor, Miles E McFall, Robert F Barnes, Murray A Raskind.   

Abstract

Twenty-two veterans with posttraumatic stress disorder (PTSD) were assessed for trauma-related nightmares and nonnightmare distressed awakenings (NNDA) before and after treatment with the alpha-1 adrenoreceptor antagonist prazosin at an average bedtime dose of 9.6 mg/day. Ratings combining frequency and intensity dimensions of trauma-related nightmares decreased from 3.6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain adrenergic activity may contribute to the pathophysiology of both trauma-related nightmares and NNDA in PTSD.

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Year:  2008        PMID： 18720392      PMCID： PMC4542062          DOI： 10.1002/jts.20351

Source DB:  PubMed          Journal:  J Trauma Stress        ISSN： 0894-9867


  14 in total

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