PURPOSE: To evaluate a new formulation of bupivacaine loaded in an injectable fatty acid based biodegradable polymer poly(lactic acid co castor oil) in prolonging motor and sensory block when injected locally. MATERIALS AND METHODS: The polyesters were synthesized from DL: -lactic acid and castor oil with feed ratio of 4:6 and 3:7 w/w. Bupivacaine was dispersed in poly(fatty ester) liquid and tested for drug release in vitro. The polymer p(DLLA:CO) 3:7 loaded with 10% bupivacaine was injected through a 22G needle close to the sciatic nerve of ICR mice and the duration of sensory and motor nerve blockade was measured. RESULTS: The DL: -lactic acid co castor oil p(DLLA:CO) 3:7 released 65% of the incorporated bupivacaine during 1 week in vitro. Single injection of 10% bupivacaine loaded into this polymer caused motor block that lasted 24 h and sensory block that lasted 48 h. CONCLUSION: Previously we developed a ricinoleic acid based polymer with incorporated bupivacaine which prolonged anesthesia to 30 h. The new polymer poly(lactic acid co castor oil) 3:7 provides slow release of effective doses of the incorporated local anesthetic agent and prolongs anesthesia to 48 h.
PURPOSE: To evaluate a new formulation of bupivacaine loaded in an injectable fatty acid based biodegradable polymer poly(lactic acid co castor oil) in prolonging motor and sensory block when injected locally. MATERIALS AND METHODS: The polyesters were synthesized from DL: -lactic acid and castor oil with feed ratio of 4:6 and 3:7 w/w. Bupivacaine was dispersed in poly(fatty ester) liquid and tested for drug release in vitro. The polymer p(DLLA:CO) 3:7 loaded with 10% bupivacaine was injected through a 22G needle close to the sciatic nerve of ICR mice and the duration of sensory and motor nerve blockade was measured. RESULTS: The DL: -lactic acid co castor oil p(DLLA:CO) 3:7 released 65% of the incorporated bupivacaine during 1 week in vitro. Single injection of 10% bupivacaine loaded into this polymer caused motor block that lasted 24 h and sensory block that lasted 48 h. CONCLUSION: Previously we developed a ricinoleic acid based polymer with incorporated bupivacaine which prolonged anesthesia to 30 h. The new polymer poly(lactic acid co castor oil) 3:7 provides slow release of effective doses of the incorporated local anesthetic agent and prolongs anesthesia to 48 h.
Authors: J Curley; J Castillo; J Hotz; M Uezono; S Hernandez; J O Lim; J Tigner; M Chasin; R Langer; C Berde Journal: Anesthesiology Date: 1996-06 Impact factor: 7.892
Authors: Daniele R de Araujo; Cíntia M S Cereda; Giovana B Brunetto; Luciana M A Pinto; Maria Helena A Santana; Eneida de Paula Journal: Can J Anaesth Date: 2004 Jun-Jul Impact factor: 5.063
Authors: Mollie S Davis; Ileana Marrero-Berrios; Isabel Perez; Charles P Rabolli; Palangat Radhakrishnan; Devasena Manchikalapati; Joseph Schianodicola; Hattiyangangadi Kamath; Rene S Schloss; Joel Yarmush Journal: J Inflamm Res Date: 2019-03-12