OBJECTIVE: The functional 577R allele of the alpha-actinin-3 (ACTN3) gene has been reported to be associated with elite power athlete status, while the nonfunctional 577XX genotype (predicts an alpha-actinin-3 deficient phenotype) has been hypothesised as providing some sort of advantage for endurance athletes. In the present study, the distribution of ACTN3 genotypes and alleles in Russian endurance-oriented athletes were examined and association between ACTN3 genotypes and the competition results of rowers were sought. METHODS: 456 Russian endurance-oriented athletes of regional or national competitive standard were involved in the study. ACTN3 genotype and allele frequencies were compared with 1211 controls. The data from the Russian Cup Rowing Tournament were used to search for possible association between the ACTN3 genotype and the long-distance (approximately 6 km) rowing results of 54 athletes. DNA was extracted from mouthwash samples. Genotyping for the R577X variant was performed by PCR and restriction enzyme digestion. RESULTS: The frequencies of the ACTN3 577XX genotype (5.7% vs 14.5%; p<0.0001) and 577X allele (33.2% vs 39.0%; p = 0.0025) were significantly lower in endurance-oriented athletes compared with the controls, and none of the highly elite athletes had the 577XX genotype. Furthermore, male rowers with ACTN3 577RR genotype showed better results (1339 (11) s) in long-distance rowing than carriers of 577RX (1386 (12) s) or 577XX (1402 (10) s) genotypes (p = 0.016). CONCLUSION: Our data show that the ACTN3 577X allele is under-represented in Russian endurance athletes and is associated with the rowers' competition results.
OBJECTIVE: The functional 577R allele of the alpha-actinin-3 (ACTN3) gene has been reported to be associated with elite power athlete status, while the nonfunctional 577XX genotype (predicts an alpha-actinin-3 deficient phenotype) has been hypothesised as providing some sort of advantage for endurance athletes. In the present study, the distribution of ACTN3 genotypes and alleles in Russian endurance-oriented athletes were examined and association between ACTN3 genotypes and the competition results of rowers were sought. METHODS: 456 Russian endurance-oriented athletes of regional or national competitive standard were involved in the study. ACTN3 genotype and allele frequencies were compared with 1211 controls. The data from the Russian Cup Rowing Tournament were used to search for possible association between the ACTN3 genotype and the long-distance (approximately 6 km) rowing results of 54 athletes. DNA was extracted from mouthwash samples. Genotyping for the R577X variant was performed by PCR and restriction enzyme digestion. RESULTS: The frequencies of the ACTN3 577XX genotype (5.7% vs 14.5%; p<0.0001) and 577X allele (33.2% vs 39.0%; p = 0.0025) were significantly lower in endurance-oriented athletes compared with the controls, and none of the highly elite athletes had the 577XX genotype. Furthermore, male rowers with ACTN3 577RR genotype showed better results (1339 (11) s) in long-distance rowing than carriers of 577RX (1386 (12) s) or 577XX (1402 (10) s) genotypes (p = 0.016). CONCLUSION: Our data show that the ACTN3 577X allele is under-represented in Russian endurance athletes and is associated with the rowers' competition results.
Authors: Agnes Mägi; Eve Unt; Ele Prans; Liina Raus; Jaan Eha; Alar Veraksitš; Külli Kingo; Sulev Kõks Journal: J Sports Sci Med Date: 2016-05-23 Impact factor: 2.988
Authors: Zudin Puthucheary; James R A Skipworth; Jai Rawal; Mike Loosemore; Ken Van Someren; Hugh E Montgomery Journal: Sports Med Date: 2011-10-01 Impact factor: 11.136
Authors: Juan Del Coso; Danielle Hiam; Peter Houweling; Laura M Pérez; Nir Eynon; Alejandro Lucía Journal: Eur J Appl Physiol Date: 2018-10-16 Impact factor: 3.078
Authors: In Wook Hwang; Kicheol Kim; Bit Na Kwon; Hyung Jun Kim; Seung Hun Han; Noo Ri Lee; Eun Ji Choi; Hyun Ik Cho; Han Jun Jin Journal: Genes Genomics Date: 2018-09-10 Impact factor: 1.839
Authors: Nir Eynon; Jonatan R Ruiz; Pedro Femia; Vladimir P Pushkarev; Pawel Cieszczyk; Agnieszka Maciejewska-Karlowska; Marek Sawczuk; Dmitry A Dyatlov; Evgeny V Lekontsev; Leonid M Kulikov; Ruth Birk; David J Bishop; Alejandro Lucia Journal: PLoS One Date: 2012-08-16 Impact factor: 3.240
Authors: Paweł Cięszczyk; Jerzy Eider; Magdalena Ostanek; Aleksandra Arczewska; Agata Leońska-Duniec; Stanisław Sawczyn; Krzysztof Ficek; Krzysztof Krupecki Journal: J Hum Kinet Date: 2011-07-04 Impact factor: 2.193