| Literature DB >> 18718756 |
Terry V Hughes1, Stuart L Emanuel, Harold R O'Grady, Peter J Connolly, Catherine Rugg, Angel R Fuentes-Pesquera, Prabha Karnachi, Richard Alexander, Steven A Middleton.
Abstract
A novel series of 7-[1H-indol-2-yl]-2,3-dihydro-isoindol-1-ones designed to be inhibitors of VEGF-R2 kinase was synthesized and found to potently inhibit VEGF-R2 and Aurora-A kinases. The structure-based design, synthesis, and initial SAR of the series are discussed.Entities:
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Year: 2008 PMID： 18718756 DOI： 10.1016/j.bmcl.2008.07.090
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823