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Literature DB >> 18718355

Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease.

Lance M Optican¹, Janet C Rucker, Edward L Keller, R John Leigh.

Abstract

In late-onset Tay-Sachs disease (LOTS), saccades are interrupted by one or more transient decelerations. Some saccades reaccelerate and continue on before eye velocity reaches zero, even in darkness. Intervals between successive decelerations are not regularly spaced. Peak decelerations of horizontal and vertical components of oblique saccades in LOTS is more synchronous than those in control subjects. We hypothesize that these decelerations are caused by dysregulation of the fastigial nuclei (FN) of the cerebellum, which fire brain stem inhibitory burst neurons (IBNs).

Entities: Disease Species

Mesh：

Year: 2008 PMID： 18718355 PMCID： PMC2750844 DOI： 10.1016/S0079-6123(08)00681-X

Source DB: PubMed Journal: Prog Brain Res ISSN： 0079-6123 Impact factor: 2.453

4 in total

1. Distributed model of collicular and cerebellar function during saccades.

Authors: Lance M Optican; Christian Quaia
Journal: Ann N Y Acad Sci Date: 2002-04 Impact factor: 5.691

2. Shared brainstem pathways for saccades and smooth-pursuit eye movements.

Authors: Edward L Keller; Marcus Missal
Journal: Ann N Y Acad Sci Date: 2003-10 Impact factor: 5.691

3. Characterization of heteropolymeric hexosaminidase A in human X mouse hybrid cells.

Authors: J Chern; E Beutler; W Kuhl; F Gilbert; W J Mellman; C M Croce
Journal: Proc Natl Acad Sci U S A Date: 1976-10 Impact factor: 11.205

4. Neuro-ophthalmology of late-onset Tay-Sachs disease (LOTS).

Authors: J C Rucker; B E Shapiro; Y H Han; A N Kumar; S Garbutt; E L Keller; R J Leigh
Journal: Neurology Date: 2004-11-23 Impact factor: 9.910

4 in total

5 in total

1. Dysfunctional mode switching between fixation and saccades: collaborative insights into two unusual clinical disorders.

Authors: Janet C Rucker; John-Ross Rizzo; Todd E Hudson; Anja K E Horn; Jean A Buettner-Ennever; R John Leigh; Lance M Optican
Journal: J Comput Neurosci Date: 2021-04-10 Impact factor: 1.621

Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease.

1. Distributed model of collicular and cerebellar function during saccades.

2. Shared brainstem pathways for saccades and smooth-pursuit eye movements.

3. Characterization of heteropolymeric hexosaminidase A in human X mouse hybrid cells.

4. Neuro-ophthalmology of late-onset Tay-Sachs disease (LOTS).

1. Dysfunctional mode switching between fixation and saccades: collaborative insights into two unusual clinical disorders.

2. Why are voluntary head movements in cervical dystonia slow?

3. The role of dentate nuclei in human oculomotor control: insights from cerebrotendinous xanthomatosis.

4. Basic and translational neuro-ophthalmology of visually guided saccades: disorders of velocity.

Review 5. Eye Movements in Parkinson's Disease and Inherited Parkinsonian Syndromes.