Literature DB >> 1871679

GABA depolarizes neurons in the rat striatum: an in vivo study.

N B Mercuri1, P Calabresi, A Stefani, F Stratta, G Bernardi.   

Abstract

GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.

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Year:  1991        PMID： 1871679     DOI： 10.1002/syn.890080106

Source DB:  PubMed          Journal:  Synapse        ISSN： 0887-4476            Impact factor:   2.562


  8 in total

1.  GABAergic excitatory synapses and electrical coupling sustain prolonged discharges in the prey capture neural network of Clione limacina.

Authors:  T P Norekian
Journal:  J Neurosci       Date:  1999-03-01       Impact factor: 6.167

2.  GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus.

Authors:  Xinmin Xie; Tara L Crowder; Akihiro Yamanaka; Stephen R Morairty; Robin D Lewinter; Takeshi Sakurai; Thomas S Kilduff
Journal:  J Physiol       Date:  2006-04-20       Impact factor: 5.182

3.  Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus.

Authors:  Xiao-Tao Jin; Jean-Francois Paré; Yoland Smith
Journal:  Eur J Neurosci       Date:  2011-03-17       Impact factor: 3.386

4.  Up and down states in striatal medium spiny neurons simultaneously recorded with spontaneous activity in fast-spiking interneurons studied in cortex-striatum-substantia nigra organotypic cultures.

Authors:  D Plenz; S T Kitai
Journal:  J Neurosci       Date:  1998-01-01       Impact factor: 6.167

5.  Fast synaptic transmission between striatal spiny projection neurons.

Authors:  Uwe Czubayko; Dietmar Plenz
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-18       Impact factor: 11.205

Review 6.  Neurochemical and physiological correlates of a critical period of respiratory development in the rat.

Authors:  Margaret T T Wong-Riley; Qiuli Liu
Journal:  Respir Physiol Neurobiol       Date:  2008-12-10       Impact factor: 1.931

7.  Altered Balance of Activity in the Striatal Direct and Indirect Pathways in Mouse Models of Huntington's Disease.

Authors:  Véronique M André; Yvette E Fisher; Michael S Levine
Journal:  Front Syst Neurosci       Date:  2011-06-16

8.  Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum.

Authors:  Sriraman Damodaran; Rebekah C Evans; Kim T Blackwell
Journal:  J Neurophysiol       Date:  2013-12-04       Impact factor: 2.974
  8 in total

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