Literature DB >> 18716713

Anticoagulation for radiation-induced neurotoxicity revisited.

Caroline Happold1, Ulrike Ernemann, Patrick Roth, Wolfgang Wick, Michael Weller, Friederike Schmidt.   

Abstract

No effective treatment for delayed radiation-induced neurotoxicity has been established. Its natural course is highly variable, but spontaneous recovery has been well documented. Here we report our experience with therapeutic anticoagulation in patients with cerebral lesions (n = 3), cranial nerve lesions (n = 1) or myelopathy (n = 4) attributed to irradiation. Two of three patients with cerebral lesions and the patient with cranial nerve lesions showed a minor improvement of clinical symptoms. In contrast, none of the patients with radiation myelopathy improved. No patient suffered hemorrhage or other adverse effects of anticoagulation. Overall, anticoagulation therapy demonstrates only modest activity for delayed radiation-induced neurotoxicity in this small case series.

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Year:  2008        PMID： 18716713     DOI： 10.1007/s11060-008-9674-6

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  13 in total

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  11 in total

1.  In search of a treatment for radiation-induced optic neuropathy.

Authors:  Maanasa Indaram; Ferhina S Ali; Marc H Levin
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Review 4.  Treatment-related changes in glioblastoma: a review on the controversies in response assessment criteria and the concepts of true progression, pseudoprogression, pseudoresponse and radionecrosis.

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Journal:  Clin Transl Oncol       Date:  2017-12-07       Impact factor: 3.405

5.  Bevacizumab as a treatment for radiation necrosis of brain metastases post stereotactic radiosurgery.

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Journal:  Neuro Oncol       Date:  2013-06-27       Impact factor: 12.300

6.  Delayed cerebral radiation necrosis after neutron beam radiation of a parotid adenocarcinoma: a case report and review of the literature.

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7.  A prospective, multicentre, single-arm clinical trial of bevacizumab for patients with surgically untreatable, symptomatic brain radiation necrosis†.

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Journal:  Pan Afr Med J       Date:  2019-07-11

Review 9.  Temporal Lobe Necrosis Following Radiotherapy in Nasopharyngeal Carcinoma: New Insight Into the Management.

Authors:  Xin Zhou; Peiyao Liu; Xiaoshen Wang
Journal:  Front Oncol       Date:  2021-01-21       Impact factor: 6.244

Review 10.  Radiation Necrosis in Intracranial Lesions.

Authors:  Sean Munier; Elizabeth E Ginalis; Nitesh V Patel; Shabbar Danish; Simon Hanft
Journal:  Cureus       Date:  2020-04-09
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