OBJECTIVE: The purpose of this study was to investigate the in vivo morphologic and elastic parameters of trabecular bone with high-resolution 3-T MRI in a healthy reference population. SUBJECTS AND METHODS: A series of wrist MR images were acquired with high-spatial-resolution (180 mum) isotropic voxels from 40 subjects without reported bone disease. After image postprocessing, the bone volume-to-total volume ratio, trabecular thickness, trabecular separation, and trabecular number were calculated in the morphologic analysis. Trabecular bone was mechanically simulated using the finite-element method to calculate the apparent elastic modulus parameter. The relationship between morphologic and mechanical parameters was studied. The influence of the analyzed bone volume was also investigated. RESULTS: Statistically significant sex influences were found on the bone volume-to-total volume ratio (p = 0.003), trabecular thickness (p = 0.02), and apparent elastic modulus (p = 0.01); these parameters were lower in women. However, trends were found only on trabecular separation (p = 0.06) and trabecular number (p = 0.07). Age had no statistically significant influence in any morphologic (bone volume-to-total volume ratio, r = -0.24, p = 0.13; trabecular thickness, r = -0.03, p = 0.88; trabecular separation, r = 0.12, p = 0.47; and trabecular number, r = -0.23, p = 0.16) or elastic (apparent elastic modulus, r = -0.18, p = 0.26) parameter. A statistically significant relationship between apparent elastic modulus and the square of bone volume-to-total volume ratio was found (r = 0.968, p < 0.001). This association was not seen (r = 0.185, p = 0.25) and apparent elastic modulus results were considerably different (p < 0.001) if the volume of analyzed bone was reduced. CONCLUSION: We found that bone volume-to-total volume ratio, trabecular thickness, and apparent elastic modulus are parameters significantly influenced by sex. Apparent elastic modulus results show a relationship with bone volume-to-total volume ratio. Trabecular bone volume should be maximized for an appropriate mechanical analysis.
OBJECTIVE: The purpose of this study was to investigate the in vivo morphologic and elastic parameters of trabecular bone with high-resolution 3-T MRI in a healthy reference population. SUBJECTS AND METHODS: A series of wrist MR images were acquired with high-spatial-resolution (180 mum) isotropic voxels from 40 subjects without reported bone disease. After image postprocessing, the bone volume-to-total volume ratio, trabecular thickness, trabecular separation, and trabecular number were calculated in the morphologic analysis. Trabecular bone was mechanically simulated using the finite-element method to calculate the apparent elastic modulus parameter. The relationship between morphologic and mechanical parameters was studied. The influence of the analyzed bone volume was also investigated. RESULTS: Statistically significant sex influences were found on the bone volume-to-total volume ratio (p = 0.003), trabecular thickness (p = 0.02), and apparent elastic modulus (p = 0.01); these parameters were lower in women. However, trends were found only on trabecular separation (p = 0.06) and trabecular number (p = 0.07). Age had no statistically significant influence in any morphologic (bone volume-to-total volume ratio, r = -0.24, p = 0.13; trabecular thickness, r = -0.03, p = 0.88; trabecular separation, r = 0.12, p = 0.47; and trabecular number, r = -0.23, p = 0.16) or elastic (apparent elastic modulus, r = -0.18, p = 0.26) parameter. A statistically significant relationship between apparent elastic modulus and the square of bone volume-to-total volume ratio was found (r = 0.968, p < 0.001). This association was not seen (r = 0.185, p = 0.25) and apparent elastic modulus results were considerably different (p < 0.001) if the volume of analyzed bone was reduced. CONCLUSION: We found that bone volume-to-total volume ratio, trabecular thickness, and apparent elastic modulus are parameters significantly influenced by sex. Apparent elastic modulus results show a relationship with bone volume-to-total volume ratio. Trabecular bone volume should be maximized for an appropriate mechanical analysis.
Authors: Saeed Jerban; Salem Alenezi; Amir Masoud Afsahi; Yajun Ma; Jiang Du; Christine B Chung; Eric Y Chang Journal: Magn Reson Imaging Date: 2022-01-25 Impact factor: 2.546
Authors: Po-Chun Chang; Li Yen Chong; Alex S M Dovban; Lum Peng Lim; Jason C Lim; Mark Yen-Ping Kuo; Chi-Hwa Wang Journal: Tissue Eng Part A Date: 2013-10-17 Impact factor: 3.845