Literature DB >> 18715785

Salicylanilides: selective inhibitors of interleukin-12p40 production.

Michael E Brown1, Jeffrey N Fitzner, Tracey Stevens, Wilson Chin, Clifford D Wright, Jim P Boyce.   

Abstract

Interleukin (IL)-12p40, a subunit component of both IL-12 and IL-23, is being widely studied for its role in inflammatory disease. As part of an effort to profile cellular signaling pathways across different cell types, we report salicylanilide inhibitors of IL-12p40 production in stimulated dendritic cells. Based on a hypothesis that a desirable therapeutic profile is one that could block IL-12p40 but not IL-6 production, we engaged in directed analoging. This resulted in salicylanilides with similar IL-12p40 related potency but enhanced selectivity relative to IL-6 production.

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Year:  2008        PMID： 18715785     DOI： 10.1016/j.bmc.2008.07.024

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme.

Authors:  Nada H El-Dershaby; Soad A El-Hawash; Shaymaa E Kassab; Hoda G Dabees; Ahmed E Abdel Moneim; Ibrahim A Abdel Wahab; Mohammad M Abd-Alhaseeb; Mostafa M M El-Miligy
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

2.  Synthesis and biological evaluation of novel 5-chloro-N-(4-sulfamoylbenzyl) salicylamide derivatives as tubulin polymerization inhibitors.

Authors:  Alaaeldin M F Galal; Maha M Soltan; Esam R Ahmed; Atef G Hanna
Journal:  Medchemcomm       Date:  2018-07-26       Impact factor: 3.597

3.  Structure-activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling.

Authors:  Ill-Young Lee; Todd D Gruber; Amanda Samuels; Minhan Yun; Bora Nam; Minseo Kang; Kathryn Crowley; Benjamin Winterroth; Helena I Boshoff; Clifton E Barry
Journal:  Bioorg Med Chem       Date:  2012-11-15       Impact factor: 3.641

4.  In vitro bactericidal activity of 4- and 5-chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA.

Authors:  Iveta Zadrazilova; Sarka Pospisilova; Karel Pauk; Ales Imramovsky; Jarmila Vinsova; Alois Cizek; Josef Jampilek
Journal:  Biomed Res Int       Date:  2015-01-15       Impact factor: 3.411

5.  The Simultaneous Inhibitory Effect of Niclosamide on RANKL-Induced Osteoclast Formation and Osteoblast Differentiation.

Authors:  Fei-Lan Liu; Chun-Liang Chen; Chia-Chung Lee; Cheng-Chi Wu; Teng-Hsu Hsu; Chang-Youh Tsai; Hsu-Shan Huang; Deh-Ming Chang
Journal:  Int J Med Sci       Date:  2017-07-19       Impact factor: 3.738

6.  Investigating spectrum of biological activity of 4- and 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides.

Authors:  Ales Imramovsky; Matus Pesko; Katarina Kralova; Marcela Vejsova; Jirina Stolarikova; Jarmila Vinsova; Josef Jampilek
Journal:  Molecules       Date:  2011-03-14       Impact factor: 4.411

7.  Investigating the spectrum of biological activity of ring-substituted salicylanilides and carbamoylphenylcarbamates.

Authors:  Jan Otevrel; Zuzana Mandelova; Matus Pesko; Jiahui Guo; Katarina Kralova; Frantisek Sersen; Marcela Vejsova; Danuta S Kalinowski; Zaklina Kovacevic; Aidan Coffey; Jozef Csollei; Des R Richardson; Josef Jampilek
Journal:  Molecules       Date:  2010-11-10       Impact factor: 4.411

8.  Antimycobacterial activity of salicylanilide benzenesulfonates.

Authors:  Martin Krátký; Jarmila Vinšová; Nabila Guisado Rodriguez; Jiřina Stolaříková
Journal:  Molecules       Date:  2012-01-05       Impact factor: 4.411

9.  Antibacterial and herbicidal activity of ring-substituted 2-hydroxynaphthalene-1-carboxanilides.

Authors:  Tomas Gonec; Jiri Kos; Iveta Zadrazilova; Matus Pesko; Rodney Govender; Stanislava Keltosova; Barbara Chambel; Diogo Pereira; Peter Kollar; Ales Imramovsky; Jim O'Mahony; Aidan Coffey; Alois Cizek; Katarina Kralova; Josef Jampilek
Journal:  Molecules       Date:  2013-08-06       Impact factor: 4.411
  9 in total

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