| Literature DB >> 18715571 |
Edgar Meinl1, Markus Krumbholz, Tobias Derfuss, Andreas Junker, Reinhard Hohlfeld.
Abstract
In multiple sclerosis (MS) the CNS is not only the target of the pathological immune response, but the CNS itself becomes an immunological compartment during the course of the disease. This comprises (i) inflammation beyond classical white matter lesions, (ii) intrathecal Ig production with oligoclonal bands, (iii) an environment fostering immune cell persistence, (iv) follicle-like aggregates in the meninges, (v) a disruption of the blood-brain barrier also outside of active lesions, which allows influx of autoantibodies possibly promoting demyelination or axonal injury and influx of fibrinogen driving inflammation.Entities:
Mesh：
Year: 2008 PMID： 18715571 DOI： 10.1016/j.jns.2008.06.032
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181