BACKGROUND: Primary neuroendocrine carcinomas of the liver have rarely been reported in humans and domestic animals, but not in non-human primates. METHODS: We describe the morphologic and immunohistochemical features of a primary hepatic neuroendocrine carcinoma found in a 29-year-old female baboon. RESULTS AND CONCLUSIONS: The neoplasm was characterized by multiple solid nodules that were multifocally distributed in the liver. Metastases were not observed. Histologically, the neoplasm was composed of cords and nests of epithelial cells arranged in a neuroendocrine pattern, occasionally forming glandular and rosette-like structures. On immunohistochemical evaluation, the neoplastic cells were immunopositive for pancytokeratin, chromogranin A, neuron-specific endolase, and synaptophysin and were negative for vimentin, S100 protein, glucagon, and insulin.
BACKGROUND:Primary neuroendocrine carcinomas of the liver have rarely been reported in humans and domestic animals, but not in non-human primates. METHODS: We describe the morphologic and immunohistochemical features of a primary hepatic neuroendocrine carcinoma found in a 29-year-old female baboon. RESULTS AND CONCLUSIONS: The neoplasm was characterized by multiple solid nodules that were multifocally distributed in the liver. Metastases were not observed. Histologically, the neoplasm was composed of cords and nests of epithelial cells arranged in a neuroendocrine pattern, occasionally forming glandular and rosette-like structures. On immunohistochemical evaluation, the neoplastic cells were immunopositive for pancytokeratin, chromogranin A, neuron-specific endolase, and synaptophysin and were negative for vimentin, S100 protein, glucagon, and insulin.
Authors: Rachel E Cianciolo; Stephanie D Butler; Jeffery S Eggers; Edward J Dick; M Michelle Leland; Melissa de la Garza; Kathleen M Brasky; Larry B Cummins; Gene B Hubbard Journal: J Med Primatol Date: 2007-04 Impact factor: 0.667
Authors: Yugendar R Bommineni; Edward J Dick; Adinarayana R Malapati; Michael A Owston; Gene B Hubbard Journal: J Med Primatol Date: 2011-01-13 Impact factor: 0.667
Authors: Edward J Dick; Michael A Owston; John M David; R Mark Sharp; Scott Rouse; Gene B Hubbard Journal: J Med Primatol Date: 2014-02-01 Impact factor: 0.667
Authors: Chandra Saravanan; Thierry Flandre; Carolyn L Hodo; Anne D Lewis; Lars Mecklenburg; Annette Romeike; Oliver C Turner; Hsi-Yu Yen Journal: ILAR J Date: 2020-12-31 Impact factor: 1.521