| Literature DB >> 18715231 |
Alan R Katritzky1, Megumi Yoshioka, Tamari Narindoshvili, Alfred Chung, Niveen M Khashab.
Abstract
N-Fmoc-protected(alpha-aminoacyl)benzotriazoles 1a-d readily afford chiral N-Fmoc-protected-alpha-dipeptides 2a-f (77-89%). Compounds 2a-f are further converted into N-Fmoc-protected(alpha-dipeptidoyl)benzotriazoles 3a-f (71% average yield). Under mild microwave irradiation, 3a-f are used in solid-phase peptide segment condensation syntheses to give tri-, tetra-, penta-, hexa-, and heptapeptides (20-68%).Entities:
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Year: 2008 PMID： 18715231 DOI： 10.1111/j.1747-0285.2008.00689.x
Source DB: PubMed Journal: Chem Biol Drug Des ISSN： 1747-0277 Impact factor: 2.817