OBJECTIVE: To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension. METHODS: A cross-sectional epidemiological study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. beta2-AR genotypes and allele frequencies at amino acid positions 16 (beta2-AR-16: Arg-->Gly) and 27 (beta2-AR-27: Gln-->Glu) were identified by PCR-RFLP. RESULTS: Job stress was related with the prevalence of hypertension in males (P < 0.05), whereas no significant relationship was found in females (P > 0.05). Differences in genotypes and allele frequencies of the beta2-AR-16 were statistically significant between the hypertension and control groups (P < 0.05), whereas those of beta2-AR-27 were not (P > 0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P < 0.01 or 0.05). CONCLUSION: High job stress and polymorphism of beta2-AR-16 have an interactive effect on the prevalence of hypertension in male workers.
OBJECTIVE: To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension. METHODS: A cross-sectional epidemiological study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensivepatients were defined by three phases of screening, reexamination, and final diagnosis. beta2-AR genotypes and allele frequencies at amino acid positions 16 (beta2-AR-16: Arg-->Gly) and 27 (beta2-AR-27: Gln-->Glu) were identified by PCR-RFLP. RESULTS: Job stress was related with the prevalence of hypertension in males (P < 0.05), whereas no significant relationship was found in females (P > 0.05). Differences in genotypes and allele frequencies of the beta2-AR-16 were statistically significant between the hypertension and control groups (P < 0.05), whereas those of beta2-AR-27 were not (P > 0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P < 0.01 or 0.05). CONCLUSION: High job stress and polymorphism of beta2-AR-16 have an interactive effect on the prevalence of hypertension in male workers.
Authors: May E Montasser; Lawrence C Shimmin; Dongfeng Gu; Jing Chen; Charles Gu; Tanika N Kelly; Cashell E Jaquish; Treva K Rice; Dabeeru C Rao; Jie Cao; Jichun Chen; Paul K Whelton; Lotuce Lee Hamm; Jiang He; James E Hixson Journal: PLoS One Date: 2014-03-21 Impact factor: 3.240