F Ashtari1, V Shaygannejad, M Akbari. 1. Department of Neurology, Isfahan Neurological Sciences Research Centre, Isfahan Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. f_ashtari@med.mui.ac.ir
Abstract
OBJECTIVE: To assess the efficacy and safety of low-dose topiramate in migraine prophylaxis vs propranolol. PATIENTS AND METHODS: A randomized, double-blind, clinical trial including 62 patients with frequent migraine headaches (> or = 3 attacks per month) was performed for a period of 8 weeks. The patients were randomly divided into two treatment groups - treated by topiramate 50 mg/day and propranolol 80 mg/day, respectively. The patients were assessed at 0, 4, and 8 weeks of the study. Results - The topiramate group showed a reduction in the mean (+/-SD) of monthly migraine frequency from 6.07 (+/-1.89) to 1.83 (+/-1.39) episodes per month, headache intensity from 7.1 (+/-1.45) to 3.67 (+/-2.1) based on the Visual Analog Scale, and headache duration from 16.37 (+/-7.26) to 6.23 (+/-5.22) hours (P < 0.001). In the patients treated with propranolol, the mean (+/-SD) of monthly headache frequency declined from 5.83 (+/-1.98) to 2.2 (+/-1.67) per month, headache intensity lessened from 6.43 (+/-1.6) to 4.13 (+/-1.94) and headache duration decreased from 15.10 (+/-6.84) to 7.27 (+/-6.46) h (P < 0.001). CONCLUSION: This study demonstrated that both low-dose topiramate and propranolol could significantly reduce migraine headache frequency, intensity, and duration. However, compared with propranolol, low-dose topiramate showed better results.
RCT Entities:
OBJECTIVE: To assess the efficacy and safety of low-dose topiramate in migraine prophylaxis vs propranolol. PATIENTS AND METHODS: A randomized, double-blind, clinical trial including 62 patients with frequent migraine headaches (> or = 3 attacks per month) was performed for a period of 8 weeks. The patients were randomly divided into two treatment groups - treated by topiramate 50 mg/day and propranolol 80 mg/day, respectively. The patients were assessed at 0, 4, and 8 weeks of the study. Results - The topiramate group showed a reduction in the mean (+/-SD) of monthly migraine frequency from 6.07 (+/-1.89) to 1.83 (+/-1.39) episodes per month, headache intensity from 7.1 (+/-1.45) to 3.67 (+/-2.1) based on the Visual Analog Scale, and headache duration from 16.37 (+/-7.26) to 6.23 (+/-5.22) hours (P < 0.001). In the patients treated with propranolol, the mean (+/-SD) of monthly headache frequency declined from 5.83 (+/-1.98) to 2.2 (+/-1.67) per month, headache intensity lessened from 6.43 (+/-1.6) to 4.13 (+/-1.94) and headache duration decreased from 15.10 (+/-6.84) to 7.27 (+/-6.46) h (P < 0.001). CONCLUSION: This study demonstrated that both low-dose topiramate and propranolol could significantly reduce migraineheadache frequency, intensity, and duration. However, compared with propranolol, low-dose topiramate showed better results.
Authors: S D Silberstein; D W Dodick; A S Lindblad; K Holroyd; M Harrington; N T Mathew; D Hirtz Journal: Neurology Date: 2012-02-29 Impact factor: 9.910
Authors: Jennifer Y Xie; Milena De Felice; Caroline M Kopruszinski; Nathan Eyde; Justin LaVigne; Bethany Remeniuk; Pablo Hernandez; Xu Yue; Naomi Goshima; Michael Ossipov; Tamara King; John M Streicher; Edita Navratilova; David Dodick; Hugh Rosen; Ed Roberts; Frank Porreca Journal: Cephalalgia Date: 2017-04-04 Impact factor: 6.292