Literature DB >> 18713055

Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa.

Junguk Park1, Gunnar F Kaufmann, J Phillip Bowen, Jack L Arbiser, Kim D Janda.   

Abstract

In Pseudomonas aeruginosa, quorum-sensing (QS) signaling regulates the expression of virulence factors and thus represents an attractive new target for anti-infective therapy. In the present study, we investigated whether solenopsin A, a venom alkaloid from the fire ant, possessed agonistic or antagonistic QS signaling activity in P. aeruginosa. We evaluated the modulation of virulence factor expression and transcriptional levels of QS-regulated genes in P. aeruginosa by solenopsin A and demonstrated that solenopsin A efficiently disrupted QS signaling. Interestingly, exogenously added C(4)-homoserine lactone (HSL), but not 3-oxo-C(12)-HSL, restored P. aeruginosa QS signaling, suggesting that solenopsin A targets the C(4)-HSL-dependent rhl QS system.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18713055     DOI： 10.1086/591916

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  16 in total

1.  Small molecules that modulate quorum sensing and control virulence in Pseudomonas aeruginosa.

Authors:  Margrith E Mattmann; Helen E Blackwell
Journal:  J Org Chem       Date:  2010-10-15       Impact factor: 4.354

Review 2.  Bacterial quorum sensing: its role in virulence and possibilities for its control.

Authors:  Steven T Rutherford; Bonnie L Bassler
Journal:  Cold Spring Harb Perspect Med       Date:  2012-11-01       Impact factor: 6.915

3.  Medicinal chemistry as a conduit for the modulation of quorum sensing.

Authors:  Colin A Lowery; Nicholas T Salzameda; Daisuke Sawada; Gunnar F Kaufmann; Kim D Janda
Journal:  J Med Chem       Date:  2010-11-11       Impact factor: 7.446

Review 4.  Productive steps toward an antimicrobial targeting virulence.

Authors:  Amy K Barczak; Deborah T Hung
Journal:  Curr Opin Microbiol       Date:  2009-07-22       Impact factor: 7.934

Review 5.  Elucidating the effect of anti-biofilm activity of bioactive compounds extracted from plants.

Authors:  Dibyajit Lahiri; Sudipta Dash; Rachayeeta Dutta; Moupriya Nag
Journal:  J Biosci       Date:  2019-06       Impact factor: 2.795

6.  Sodium houttuyfonate affects production of N-acyl homoserine lactone and quorum sensing-regulated genes expression in Pseudomonas aeruginosa.

Authors:  Daqiang Wu; Weifeng Huang; Qiangjun Duan; Fang Li; Huijuan Cheng
Journal:  Front Microbiol       Date:  2014-11-26       Impact factor: 5.640

Review 7.  The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.

Authors:  Tsiry Rasamiravaka; Quentin Labtani; Pierre Duez; Mondher El Jaziri
Journal:  Biomed Res Int       Date:  2015-03-19       Impact factor: 3.411

8.  The post-antibiotic era: promising developments in the therapy of infectious diseases.

Authors:  Mario Zucca; Dianella Savoia
Journal:  Int J Biomed Sci       Date:  2010-06

9.  At a supra-physiological concentration, human sexual hormones act as quorum-sensing inhibitors.

Authors:  Amélie Beury-Cirou; Mélanie Tannières; Corinne Minard; Laurent Soulère; Tsiry Rasamiravaka; Robert H Dodd; Yves Queneau; Yves Dessaux; Catherine Guillou; Olivier M Vandeputte; Denis Faure
Journal:  PLoS One       Date:  2013-12-23       Impact factor: 3.240

Review 10.  Quorum quenching agents: resources for antivirulence therapy.

Authors:  Kaihao Tang; Xiao-Hua Zhang
Journal:  Mar Drugs       Date:  2014-05-30       Impact factor: 5.118
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.