Literature DB >> 18712315

Genetic signatures for a rodent model of Parkinson's disease using combinatorial optimization methods.

Mou'ath Hourani1, Regina Berretta, Alexandre Mendes, Pablo Moscato.   

Abstract

This chapter illustrates the use of the combinatorial optimization models presented in Chapter 19 for the Feature Set selection and Gene Ordering problems to find genetic signatures for diseases using micro-array data. We demonstrate the quality of this approach by using a microarray dataset from a mouse model of Parkinson's disease. The results are accompanied by a description of the currently known molecular functions and biological processes of the genes in the signatures.

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Year:  2008        PMID： 18712315     DOI： 10.1007/978-1-60327-429-6_20

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  8 in total

1.  Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates.

Authors:  Pankaj Goyal; Antje Behring; Abhishek Kumar; Wolfgang Siess
Journal:  PLoS One       Date:  2009-09-16       Impact factor: 3.240

2.  Differences in abundances of cell-signalling proteins in blood reveal novel biomarkers for early detection of clinical Alzheimer's disease.

Authors:  Mateus Rocha de Paula; Martín Gómez Ravetti; Regina Berretta; Pablo Moscato
Journal:  PLoS One       Date:  2011-03-24       Impact factor: 3.240

3.  Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.

Authors:  Martín Gómez Ravetti; Osvaldo A Rosso; Regina Berretta; Pablo Moscato
Journal:  PLoS One       Date:  2010-04-13       Impact factor: 3.240

4.  A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis.

Authors:  Carlos Riveros; Drew Mellor; Kaushal S Gandhi; Fiona C McKay; Mathew B Cox; Regina Berretta; S Yahya Vaezpour; Mario Inostroza-Ponta; Simon A Broadley; Robert N Heard; Stephen Vucic; Graeme J Stewart; David W Williams; Rodney J Scott; Jeanette Lechner-Scott; David R Booth; Pablo Moscato
Journal:  PLoS One       Date:  2010-12-01       Impact factor: 3.240

5.  Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34+ Cells Deficient in MicroRNA-377.

Authors:  Darukeshwara Joladarashi; Venkata Naga Srikanth Garikipati; Rajarajan A Thandavarayan; Suresh K Verma; Alexander R Mackie; Mohsin Khan; Anna M Gumpert; Arvind Bhimaraj; Keith A Youker; Cesar Uribe; Sahana Suresh Babu; Prince Jeyabal; Raj Kishore; Prasanna Krishnamurthy
Journal:  J Am Coll Cardiol       Date:  2015-11-17       Impact factor: 24.094

6.  STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells.

Authors:  Pankaj Goyal; Antje Behring; Abhishek Kumar; Wolfgang Siess
Journal:  PLoS One       Date:  2011-01-20       Impact factor: 3.240

7.  STK35 Gene Therapy Attenuates Endothelial Dysfunction and Improves Cardiac Function in Diabetes.

Authors:  Darukeshwara Joladarashi; Yanan Zhu; Matthew Willman; Kevin Nash; Maria Cimini; Rajarajan Amirthalingam Thandavarayan; Keith A Youker; Xuehong Song; Di Ren; Ji Li; Raj Kishore; Prasanna Krishnamurthy; Lianchun Wang
Journal:  Front Cardiovasc Med       Date:  2022-01-13

8.  Heterogeneous Ensemble Combination Search Using Genetic Algorithm for Class Imbalanced Data Classification.

Authors:  Mohammad Nazmul Haque; Nasimul Noman; Regina Berretta; Pablo Moscato
Journal:  PLoS One       Date:  2016-01-14       Impact factor: 3.240
  8 in total

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