| Literature DB >> 1871183 |
A Hornych1, F Forette, J Bariéty, C Krief, J Aumont, M Paris.
Abstract
The purpose of our study was to determine influence of age on renal prostaglandin (PG) synthesis in man. Urinary prostaglandins 6-Keto-PGF1 alpha, TxB2, PGE2 and PGF2 alpha were measured in 45 normotensive subjects aged from 20-95 years. Urinary 6-Keto-PGF1 alpha excretion, reflecting mainly renal cortical prostacyclin synthesis, decreased significantly with age, while urinary TxB2 showed the opposite development. The ratio of urinary 6-Keto-PGF1 alpha/TxB2 decreased with age. PGE2 excretion was preserved in old subjects probably because the age-dependent decrease in renal function concerns mainly the cortex and spares the medulla. PGF2 alpha synthesis was least influenced by age. This age-dependent decrease in renal prostacyclin synthesis may play a role in the renal alterations of the elderly.Entities:
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Year: 1991 PMID： 1871183 DOI： 10.1016/0952-3278(91)90168-5
Source DB: PubMed Journal: Prostaglandins Leukot Essent Fatty Acids ISSN： 0952-3278 Impact factor: 4.006