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Literature DB >> 18711435

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking.

Hekla Sigmundsdottir¹, Eugene C Butcher.

Abstract

Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)(2)D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells.

Entities: Chemical Disease Gene Species

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Year: 2008 PMID： 18711435 PMCID： PMC3171274 DOI： 10.1038/ni.f.208

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

69 in total

Review 1. The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders.

Authors: Michael P Schön; Thomas M Zollner; W Henning Boehncke
Journal: J Invest Dermatol Date: 2003-11 Impact factor: 8.551

2. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27.

Authors: Hekla Sigmundsdottir; Junliang Pan; Gudrun F Debes; Carsten Alt; Aida Habtezion; Dulce Soler; Eugene C Butcher
Journal: Nat Immunol Date: 2007-01-28 Impact factor: 25.606

Review 3. The RXR heterodimers and orphan receptors.

Authors: D J Mangelsdorf; R M Evans
Journal: Cell Date: 1995-12-15 Impact factor: 41.582

4. Rules of chemokine receptor association with T cell polarization in vivo.

Authors: C H Kim; L Rott; E J Kunkel; M C Genovese; D P Andrew; L Wu; E C Butcher
Journal: J Clin Invest Date: 2001-11 Impact factor: 14.808

5. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).

Authors: B Homey; W Wang; H Soto; M E Buchanan; A Wiesenborn; D Catron; A Müller; T K McClanahan; M C Dieu-Nosjean; R Orozco; T Ruzicka; P Lehmann; E Oldham; A Zlotnik
Journal: J Immunol Date: 2000-04-01 Impact factor: 5.422

6. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.

Authors: Daniel Mucida; Yunji Park; Gisen Kim; Olga Turovskaya; Iain Scott; Mitchell Kronenberg; Hilde Cheroutre
Journal: Science Date: 2007-06-14 Impact factor: 47.728

7. Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues.

Authors: Daniel J Campbell; Eugene C Butcher
Journal: J Exp Med Date: 2002-01-07 Impact factor: 14.307

8. PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.

Authors: Istvan Szatmari; Attila Pap; Ralph Rühl; Jiang-Xing Ma; Petr A Illarionov; Gurdyal S Besra; Eva Rajnavolgyi; Balazs Dezso; Laszlo Nagy
Journal: J Exp Med Date: 2006-09-18 Impact factor: 14.307

9. Commensal bacteria and expression of two major intestinal chemokines, TECK/CCL25 and MEC/CCL28, and their receptors.

Authors: François Meurens; Mustapha Berri; Richard H Siggers; Benjamin P Willing; Henri Salmon; Andrew G Van Kessel; Volker Gerdts
Journal: PLoS One Date: 2007-07-25 Impact factor: 3.240

10. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.

Authors: Cheng-Ming Sun; Jason A Hall; Rebecca B Blank; Nicolas Bouladoux; Mohamed Oukka; J Rodrigo Mora; Yasmine Belkaid
Journal: J Exp Med Date: 2007-07-09 Impact factor: 14.307

139 in total

Review 1. Beyond the classical: influenza virus and the elucidation of alternative MHC class II-restricted antigen processing pathways.

Authors: Laurence C Eisenlohr; Nancy Luckashenak; Sebastien Apcher; Michael A Miller; Gomathinayagam Sinnathamby
Journal: Immunol Res Date: 2011-12 Impact factor: 2.829

Review 10. Translational Mini-Review Series on Vaccines for HIV: T lymphocyte trafficking and vaccine-elicited mucosal immunity.

Authors: D R Kaufman; D H Barouch
Journal: Clin Exp Immunol Date: 2009-08 Impact factor: 4.330

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking.

Review 1. The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders.

2. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27.

Review 3. The RXR heterodimers and orphan receptors.

4. Rules of chemokine receptor association with T cell polarization in vivo.

5. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).

6. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.

7. Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues.

8. PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.

9. Commensal bacteria and expression of two major intestinal chemokines, TECK/CCL25 and MEC/CCL28, and their receptors.

10. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.

Review 1. Beyond the classical: influenza virus and the elucidation of alternative MHC class II-restricted antigen processing pathways.

Review 2. Tissue-specific homing of immune cells in malignant skin tumors.

Review 3. Generation, persistence and plasticity of CD4 T-cell memories.

Review 4. Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity.

5. Plasmablast-derived polyclonal antibody response after influenza vaccination.

Review 6. Integrin function in T-cell homing to lymphoid and nonlymphoid sites: getting there and staying there.

Review 7. Regulation of immunity at tissue sites of inflammation.

8. 1,25-Dihydroxyvitamin D3 selectively and reversibly impairs T helper-cell CNS localization.

Review 9. Targeting cells in motion: migrating toward improved therapies.

Review 10. Translational Mini-Review Series on Vaccines for HIV: T lymphocyte trafficking and vaccine-elicited mucosal immunity.