| Literature DB >> 18711000 |
Qing Lan1, Unhee Lim, Chin-San Liu, Stephanie J Weinstein, Stephen Chanock, Matthew R Bonner, Jarmo Virtamo, Demetrius Albanes, Nathaniel Rothman.
Abstract
Mitochondrial DNA (mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor. We hypothesized that having a higher mtDNA copy number in peripheral white blood cell DNA from healthy subjects would be associated with future risk of non-Hodgkin lymphoma (NHL). We analyzed mtDNA copy number in 104 incident male NHL cases and 104 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention cohort. There was a dose-response relationship between tertiles of mtDNA copy number and risk of NHL (odds ratio [OR], 95% confidence interval [CI]: 1.0; 1.4 [0.7-2.8]; and 2.4 [1.0-5.5], respectively; P(trend) = .046). The effect was most pronounced for the CLL/small lymphocytic lymphoma (SLL) subtype (OR: 1.0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; P(trend) = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/SLL.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18711000 PMCID： PMC2582005 DOI： 10.1182/blood-2008-05-157974
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113