| Literature DB >> 18710790 |
Xiaolei Zhou1, Yi Liu, Jiacong You, Hang Zhang, Xiaodong Zhang, Lihong Ye.
Abstract
Myosin light-chain kinase (MLCK) plays a crucial role in the cell migration and tumor metastasis. Herein, we investigated the signaling pathways involved in MLCK using ML-7, a specific inhibitor of MLCK, in breast cancer cell proliferation and migration. Our data showed that reduction of MLCK in breast cancer cells mediated by 20 microM ML-7 was able to depress the cell proliferation and migration using two parallel cell lines (MCF-7 and LM-MCF/MDA-MB-231) with different metastatic abilities through reciprocal cross-talk with activated ERK1/2, in which both phosphorylated myosin light chain (p-MLC) and cascades of beta-catenin, cyclin D1, survivin, and c-Myc serve as essential downstream effectors.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18710790 DOI： 10.1016/j.canlet.2008.05.028
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679